How To Get Antidepressants

Daniel Z. Lieberman, MD

Reviewed by Daniel Z. Lieberman, MD

Written by Taylor Trudon

Published 05/12/2021

Updated 02/01/2024

When you’re depressed, seemingly small tasks or activities like brushing your teeth, cooking your favorite carbonara or grabbing after-work drinks can feel like an enormous hurdle. And mustering the strength — and vulnerability — to ask for help in your darkest moments can feel nearly impossible. 

Whether you’ve been marinating in a two-week funk or have been struggling with severe depression for years, you are not alone. Worldwide, nearly 300 million adults suffer from this mental health disorder.

Fortunately, there are coping strategies and treatment plans that can help make living with this disease feel less debilitating. Along with mental health resources like talk therapy, antidepressant medication is one of the most effective treatments healthcare providers recommend.

But how do you get it? What kind of antidepressant is right for you? And how do these prescription drugs work? We’ll unpack these questions and more below.

How to Get Antidepressants

While not as quick as adding a pair of shoes to your online shopping cart, getting prescribed antidepressants isn’t as difficult as you might think. But to get these meds, you do need to have a prescription from a healthcare provider.

There are a few ways to go about this: 

  • Talk to your primary care provider. Based on your symptoms (and any other coexisting medical conditions you might have), a primary care provider (PCP) can direct you to the right kind of medication. In addition to medication, your PCP may also recommend other forms of treatment, like group therapy or psychotherapy.

  • Get a referral from a therapist or psychiatrist. A therapist cannot prescribe depression medication, but a psychiatrist or a psychiatric nurse can. Making an appointment with a therapist is a good starting point because they can provide coping strategies based on your symptoms of depression in addition to connecting you with a psychiatrist.

  • Utilize online telehealth platforms. If you don’t feel like making the trip to the doctor’s office (understandable!), you can also get antidepressants online, along with support through telehealth primary care platforms like Hers. 

Lastly, over-the-counter alternatives might offer benefits when taken with prescription antidepressants.

A handful of the most popular ones include: 

While some research speaks to the effectiveness of the above supplements, it’s important to point out that there’s still uncertainty regarding factors like taking the correct doses and how those doses interact with other medications.

Some experts are against using OTC supplements because active ingredients vary by brand and individual batches, delivering unpredictable results.

If you decide to dip your feet into the over-the-counter antidepressant alternative pond, it’s worth saying this: OTC antidepressants aren’t technically antidepressants, and they’re not a replacement for seeking professional help.

When in doubt, always talk to a healthcare provider.

It’s totally normal to get down in the dumps, especially when you’re going through a rough patch, like a breakup or a job loss. But when those feelings become more intense and prolonged, you might start to wonder if you need antidepressants.

Antidepressants are most commonly prescribed for people who have major depressive disorder (MDD). MDD is described as feeling depressed, moody or sad all, every day, for at least two weeks.

For many, the first step in talking about mental health struggles begins with a primary care provider. While you might associate your PCP as that person who gives you your annual physical or writes a prescription when you get a gnarly sinus infection, they can actually be a great first stop on the train toward treatment. 

To make a diagnosis, a healthcare professional may ask you if you’re experiencing symptoms of MDD, such as:

  • Sleep disruption

  • Weight gain or weight loss

  • Trouble making decisions

  • Feelings of worthlessness

  • Suicidal thoughts or frequent thoughts about death

  • Decreased energy, fatigue or feeling “slowed down”

Depression enters some people’s lives in waves depending on life circumstances. For others, the mental health condition might feel like a more permanent fixture — like a bad roommate who just won’t move out.

Your healthcare provider will likely want to know how long you’ve been experiencing these symptoms, their severity and how your symptoms are presented before making an official diagnosis.

Feeling stuck on how to start the convo with your healthcare provider? Our guide on how to ask your doctor for antidepressants has some pointers to help you feel more confident in talking about your symptoms.

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your mental health journey starts here

When people talk about antidepressants, it may seem like they’re referring to one kind of pill that magically works for everyone. While that would definitely make things more convenient, it’s simply not the case.

The reality is, there’s no one-size-fits-all treatment. There are multiple types of antidepressants, and each person responds to them differently.

How long a person takes an antidepressant varies. Some people may need antidepressants for a relatively short period (like while grieving the loss of a loved one), or they might need medication long-term, if the depression is chronic. 

These are the most common antidepressants prescribed to patients:

  • Selective serotonin reuptake inhibitors (SSRIs)

  • Serotonin and norepinephrine reuptake inhibitors (SNRIs)

  • Tricyclic antidepressants (TCAs)

  • Bupropion

Let’s get to know each one better. 


The most commonly prescribed SSRIs include

SSRIs (short for selective serotonin reuptake inhibitors) boost your serotonin levels. Many healthcare professionals consider them a first line of treatment for major depressive disorder as well as anxiety disorders.


The most commonly prescribed SNRIs are: 

  • Venlafaxine (Effexor XR®)

  • Desvenlafaxine (Pristiq®)

  • Duloxetine (Cymbalta®)

  • Milnacipran (Savella®)

  • Levomilnacipran (Fetzima®)

SNRIs (serotonin-norepinephrine reuptake inhibitors) are also responsible for increasing serotonin levels. They double up by targeting another neurotransmitter called norepinephrine.

Norepinephrine is like the PTA mom who has her hands full: She helps regulate your sleep-wake cycle, stimulates your cardiovascular system and is involved in your body’s fight-or-flight response, among other tasks.

Low levels of norepinephrine are linked to symptoms like lethargy and poor concentration. By targeting both serotonin and norepinephrine, SNRI medication can be effective in treating anxiety and depression.

Tricyclic Antidepressants (TCAs)

Tricyclic antidepressants (or TCAs) are a type of antidepressant developed in the 20th century. They’re among some of the first prescription medications to be approved by the FDA.

Lots of people still use TCAs, though they’ve largely been replaced with other medications, like SSRIs and SNRIs. However, if you’re experiencing depression and those aforementioned meds aren’t cutting it, your healthcare provider might recommend TCAs as an alternative.

For more details on how these drugs work and what side effects to expect, check out our tricyclic antidepressants guide.


Bupropion is another antidepressant used for the treatment of depression as well as seasonal affective disorder (SAD). It’s sold under the brand names: 

  • Wellbutrin®

  • Wellbutrin SR®

  • Wellbutrin XL® 

  • Aplenzin®

  • Forfivo® XL (for major depressive disorder)

Bupropion belongs to a group of medications known as aminoketones. It impacts the way your body uses neurotransmitters like dopamine and norepinephrine to help regulate your moods. People with depression may have lower dopamine and norepinephrine levels, and bupropion works by increasing them.

You might be surprised to learn that bupropion is also commonly used as a smoking cessation medication (sold under the brand name Zyban®). Research shows it can help reduce tobacco cravings and withdrawal symptoms in ex-smokers. So if you hear someone say they’re taking Wellbutrin® to kick their smoking habit, this is what they’re referring to.

Unlike other antidepressants, bupropion is known to cause fewer and less severe adverse symptoms, like drowsiness, weight loss, weight gain and sexual dysfunction. 

It’s worth noting that many of these common antidepressants don’t work instantly, and it may take some time for your body to adjust. Our full antidepressants list goes over additional medication options, as well as more in-depth information on how they work.

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psychiatrist-backed care, all from your couch

Everyone’s mental health journey looks different. Your personal road to recovery may include antidepressants, and that’s perfectly normal.

But if you start to feel overwhelmed, remember:

  • A healthcare provider can help. In order to get antidepressants, you first need a prescription. A healthcare professional can ask you about your symptoms to determine which antidepressant is right for you.

  • There are many types of antidepressants. There’s no one-size-fits-all option when it comes to medication. What works for someone else may not work for you, and vice versa.

  • You have other support. Support can look like leaning on loved ones, connecting with friends or spending time with a pet. It can also look like mental health services or resources, be it online therapy or anonymous support groups. The important thing is finding a system that works for you. 

Seeking help for your depression can be scary, but your mental health is worth fighting for. Get started today.

14 Sources

Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references.

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This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standards here.

Daniel Z. Lieberman, MD

Dr. Daniel Z. Lieberman is the senior vice president of mental health at Hims & Hers and of psychiatry and behavioral sciences at George Washington University. Prior to joining Hims & Hers, Dr. Lieberman spent over 25 years as a full time academic, receiving multiple awards for teaching and research. While at George Washington, he served as the chairman of the university’s Institutional Review Board and the vice chair of the Department of Psychiatry and Behavioral Sciences.

Dr. Lieberman’s has focused on , , , and to increase access to scientifically-proven treatments. He served as the principal investigator at George Washington University for dozens of FDA trials of new medications and developed online programs to help people with , , and . In recognition of his contributions to the field of psychiatry, in 2015, Dr. Lieberman was designated a distinguished fellow of the American Psychiatric Association. He is board certified in psychiatry and addiction psychiatry by the American Board of Psychiatry and Neurology.

As an expert in mental health, Dr. Lieberman has provided insight on psychiatric topics for the U.S. Department of Health and Human Services, U.S. Department of Commerce, and Office of Drug & Alcohol Policy.

Dr. Lieberman studied the Great Books at St. John’s College and attended medical school at New York University, where he also completed his psychiatry residency. He is the coauthor of the international bestseller , which has been translated into more than 20 languages and was selected as one of the “Must-Read Brain Books of 2018” by Forbes. He is also the author of . He has been on and to discuss the role of the in human behavior, , and .


  • 1992: M.D., New York University School of Medicine

  • 1985: B.A., St. John’s College, Annapolis, Maryland

Selected Appointments

  • 2022–Present: Clinical Professor, George Washington University Department of Psychiatry and Behavioral Sciences

  • 2013–2022: Vice Chair for Clinical Affairs, George Washington University Department of Psychiatry and Behavioral Sciences

  • 2010–2022: Professor, George Washington University Department of Psychiatry and Behavioral Sciences

  • 2008–2017: Chairman, George Washington University Institutional Review Board

Selected Awards & Honors

  • 2022: Distinguished Life Fellow, American Psychiatric Association

  • 2008–2020: Washingtonian Top Doctor award

  • 2005: Caron Foundation Research Award


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