FDA approved

Generic for Prozac®Fluoxetine

Starting at $49/mo

Getting psychiatric care for anxiety and depression has never been more convenient. Consult with a healthcare provider through our platform to determine whether a medication like fluoxetine could be right for you.


  • Prescribed by a healthcare provider experienced in treating anxiety & depression, if appropriate
  • Unlimited provider messaging
  • Free dosage adjustments

What is fluoxetine?

Fluoxetine is an antidepressant, notably the first SSRI (selective serotonin reuptake inhibitor) approved for use in the United States. It has been approved by the FDA and marketed under the brand name Prozac® for over three decades.

Fluoxetine uses

  • Currently, fluoxetine is FDA-approved for acute and maintenance treatment of major depressive disorder (MDD), as well as obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder. Not all mental health conditions can be treated by a provider through our platform.
  • Fluoxetine should be taken exactly as directed by your healthcare provider. Generally, it is taken once a day at the same time, earlier in the day if trouble sleeping is a concern. Abruptly stopping fluoxetine is generally not recommended, even if you feel better, because serious withdrawal symptoms can occur.

How fluoxetine works

Fluoxetine works to increase the amount of serotonin in the brain by limiting how much serotonin is reabsorbed by nerve cells. For people with depression and anxiety, this can help manage symptoms such as low interest in activities or panic attacks.

* Only available if prescribed after an online consultation with a healthcare provider.

* Controlled substances such as Xanax and Adderall are not available through our platform.

* This page has been medically reviewed by Sylvia Valadez, MSN, APRN, FNP-BC.

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Fluoxetine Generic for Prozac®

How to get fluoxetine online with Hers

1. Simple consultation

Complete an online mental health assessment and intake form, then connect with a healthcare provider through our platform.

2. Free delivery

Get fluoxetine shipped to you for free, if prescribed.

3. Ongoing support

Enjoy secure, ongoing support 100% online—including refills and unlimited dosage adjustments.

What’s an SSRI?

Selective serotonin reuptake inhibitors (SSRIs) are a type of antidepressant that work by increasing levels of a mood-affecting chemical called serotonin in the brain which helps to improve your symptoms. Nice, right?

The science of fluoxetine

Your brain naturally produces chemicals that make you feel good, like serotonin. Fluoxetine keeps neurons from reabsorbing this chemical so that you have more of it available in your brain. Long story short? For people with depression and anxiety disorders, this can help to improve interest in activities or reduce the number of panic attacks.


Good to know

Potential fluoxetine side effects

The most common side effects of fluoxetine include unusual dreams, sexual problems, loss of appetite, diarrhea, indigestion, nausea or vomiting, weakness, dry mouth, flu symptoms, feeling tired or fatigued, change in sleep habits, yawning, sinus infection or sore throat, tremor or shaking, sweating, feeling anxious or nervous, hot flashes, and rash. Discuss any side effects you experience with your provider.


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Felt better

Over 75% of Hers customers who checked in with their provider reported improvements in their mental health symptoms.*

* Results vary. Data were self-reported between 11/26/2021 and 08/01/2022 by Hers customers who 1) signed up between 11/04/2021 and 05/04/2022; 2) were prescribed antidepressant medication by a provider after their first consultation on the Hers platform; and 3) had an active subscription for such psychiatric medication through the Hers platform within 90 days after signing up.

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How Does Fluoxetine Work?

Fluoxetine Side Effects

Frequently asked questions about fluoxetine

How does fluoxetine (generic for Prozac®) make you feel?

Fluoxetine has been shown to be effective in treating depression and certain types of anxiety in clinical trials.

How long does fluoxetine take to work?

Fluoxetine may take up to two weeks to begin its work on depression and will continue to improve working over time.

What does fluoxetine do?

Fluoxetine blocks the reuptake of serotonin, a neurotransmitter or chemical messenger in the brain.

Is fluoxetine an MAOI?

No, fluoxetine is not an MAOI (monoamine oxidase inhibitor). It is an SSRI.

Is fluoxetine a controlled substance?

No. Fluoxetine is an SSRI, which is not a controlled substance. Most people do not abuse SSRIs.

Is fluoxetine (generic for Prozac®) addictive?

Fluoxetine has not been systematically studied for its potential for abuse, tolerance, or physical dependence and is not known to have addictive properties. Quitting fluoxetine without talking to a healthcare provider is not recommended, as discontinuing fluoxetine could cause serious discontinuation symptoms. You should always consult a healthcare provider before stopping fluoxetine.

Does fluoxetine (generic for Prozac®) cause weight gain?

While antidepressants are sometimes associated with minor weight gain, in clinical studies of fluoxetine, a small number of patients reported decreased appetite and/or weight loss, which may be more significant in underweight depressed or bulimic patients. Consult your healthcare provider with any questions about the potential for weight gain while taking fluoxetine.

How long does fluoxetine stay in your system?

After you stop taking fluoxetine, it should be out of your system in about 25 days. However, certain metabolites may stay in your system for 22 to 82 days after stopping the medication.

What are some possible serious side effects of fluoxetine?

Adverse effects of fluoxetine may include drowsiness, irregular heartbeat, seizures, abnormal bleeding or bruising, suicidal thoughts or serious allergic reaction. This list is nonexhaustive.
If you experience these or worsening side effects, contact a healthcare professional immediately.

What are some known fluoxetine interactions?

Drug interactions with fluoxetine include: MAOIs (such as isocarboxazid or tranylcypromine), NSAIDs (such as ibuprofen), certain beta-blockers, tricyclic antidepressants, warfarin, benzodiazepines, certain anti-psychotics, certain anticonvulsants and more (including St. John‘s Wort). If mixed with certain antidepressants that increase serotonin, you may run the risk of a serious condition called serotonin syndrome. This list is non-exhaustive.
Be sure to seek medical advice from a healthcare professional and read the package information before beginning fluoxetine treatment.

Learn more about fluoxetine

Important safety information

Learn more about fluoxetine

Important safety information

Important Safety Information

Do not take Fluoxetine if you:
  • are allergic to Fluoxetine, or any of the ingredients in Fluoxetine
  • take any medicines called monoamine oxidase inhibitor (MAOI), or if you have stopped taking an MAOI within the last 14 days
  • taking tamoxifen
  • are drinking alcohol
  • are using or abusing recreation drugs or prescription medications
Fluoxetine can cause serious side effects. Rarely reported side effects include:
  • low sodium blood levels (symptoms may include headache, weakness and difficulty remembering or concentrating)
  • angle closure glaucoma (symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye)
  • serotonin syndrome (symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death)
  • increased bleeding (gums)
  • seizure
  • teeth grinding
  • QT prolongation and ventricular arrhythmia including Torsades de Pointes (changes in the electrical activity of your heart; symptoms may include fast, slow or irregular heartbeat, shortness of breath, and dizziness or fainting)
  • increased risk of bleeding events when combined with use of aspirin, nonsteroidal anti-inflammatory drugs (e.g. ibuprofen, naproxen), warfarin, and other anticoagulants
Before you take Fluoxetine, tell your healthcare provider if you:
  • have thoughts of suicide or harming yourself
  • have a history of psychiatric or medical problems, including bipolar disorder
  • have taken any medication in the past for your condition, whether effective or not
  • have suffered adverse or side effects from previous medication therapies
  • are receiving any non-medication treatment, such as talk therapy
  • drink alcohol or use/abuse recreational or prescription drugs
  • are pregnant, plan to become pregnant, or are breastfeeding
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements, and recreational drugs.
Fluoxetine may affect the way other medicines work, and other medicines may affect the way Fluoxetine works, causing side effects. Especially tell your healthcare provider if you take any of the following:
  • aspirin, nonsteroidal anti-inflammatory drugs (e.g. ibuprofen, naproxen)
  • warfarin, and other anticoagulants
  • any other serotonergic medications, migraine medications (triptans), pain medications, antibiotic linezolid, amphetamines
  • anticonvulsants (phenytoin, carbamazepine)
  • antipsychotics (haloperidol, aripiprazole)
  • atomoxetine
  • tricyclic antidepressants (imipramine, desipramine)
  • beta blockers (metoprolol, propranolol)
  • tamoxifen
During treatment with this medication, the side effects of this medication may go away as your body adjusts to the medication. The most common side effects of Fluoxetine: headache, nausea, diarrhea, dry mouth, increased sweating, feeling nervous, restless, fatigued, sleepy or having trouble sleeping (insomnia). Sexual side effects, such as problems with orgasm or ejaculatory delay often do not diminish over time.
Fluoxetine is a prescription medicine used to treat major depressive disorder (MDD), obsessive compulsive disorder (OCD), panic disorder, bulimia nervosa, and premenstrual dysphoric disorder (PMDD). (may also be helpful when prescribed “off-label” for body dysmorphic disorder, dysthymia, or posttraumatic stress disorder (PTSD).)
The delayed release form should be swallowed whole. Do not break, crush or chew it.
If you miss a dose of fluoxetine that you take daily, take it as soon as you remember, unless it is closer to the time of your next dose. If you take fluoxetine once weekly, take it as soon as possible, then go back to your regular schedule the next week. Discuss this with your healthcare provider. Do not double your next dose or take more than what is prescribed.
Do not stop taking fluoxetine, even when you feel better. Abruptly stopping can cause withdrawal symptoms including: vomiting, irritability, dizziness, headaches, sensation of tingling skin, or nightmares.
Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.
Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient’s prescriber or healthcare professional. All patients being treated with antidepressants for any indication should watch for and notify their healthcare provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.
If you no longer need your medication, the best way to dispose of most types of old, unused, unwanted, or expired medicines (both prescription and over the counter) is to drop off the medicine at a drug take back site, location, or program immediately. You can use the DEA DIVERSION CONTROL DIVISION LOOKUP to find your nearest drug disposal site.
If no drug take back sites, locations, or programs are available in your area, and there are no specific disposal instructions (such as flushing) in the medication guide or package insert, you can follow these simple steps to dispose of most medicines in your trash at home:
  • Mix medicines (liquid or pills; do not crush tablets or capsules) with an unappealing substance such as dirt, cat litter, or used coffee grounds;
  • Place the mixture in a container such as a sealed plastic bag;
  • Throw away the container in your trash at home; and
  • Delete all personal information on the prescription label of empty medicine bottles or medicine packaging, then trash or recycle the empty bottle or packaging
If you're in emotional distress, text HOME to 741-741 to connect with a Crisis Text Line counselor immediately.
If you're having a medical or mental health emergency, call 911 or go to your local ER

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* Controlled substances, including amphetamines (such as Adderall) or benzodiazepines (such as Xanax and Valium) are not available through our platform.