FDA approved

Generic for Zoloft®Sertraline

Starting at $49/mo

Getting psychiatric care for anxiety and depression has never been more convenient. Consult with a healthcare provider through our platform to determine whether a medication like sertraline could be right for you.


  • Prescribed by a healthcare provider experienced in treating anxiety & depression, if appropriate
  • Unlimited provider messaging
  • Free dosage adjustments

What is sertraline?

Sertraline is a prescription drug and was one of the first SSRI (selective serotonin reuptake inhibitor) antidepressants on the US market. Sertraline is marketed under the brand name Zoloft®, which was first approved by the Food and Drug Administration in 1992 as a treatment of major depressive disorder.

Sertraline uses

Currently, sertraline is approved by the FDA to treat major depressive disorder (MDD), as well as obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder. Not all mental health conditions can be treated by a provider through our platform.

How sertraline works

Sertraline (generic for Zoloft®) works by controlling the amount of serotonin that is reabsorbed by neurons in the brain, which increases the amount of free serotonin in the brain. For people with depression and anxiety disorders, this can help to improve their interest in activities or reduce their number of panic attacks.

* Only available if prescribed after an online consultation with a healthcare provider.

* Controlled substances such as Xanax and Adderall are not available through our platform.

* This page has been medically reviewed by Sylvia Valadez, MSN, APRN, FNP-BC.

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Sertraline Generic for Zoloft®

How to get sertraline online with Hers

1. Simple consultation

Complete an online mental health assessment and intake form, then connect with a healthcare provider through our platform.

2. Free delivery

Get sertraline shipped to you for free, if prescribed.

3. Ongoing support

Enjoy secure, ongoing support 100% online—including refills and unlimited dosage adjustments.

What’s an SSRI?

Selective serotonin reuptake inhibitors (SSRIs) are a type of antidepressant that work by increasing levels of a mood-affecting chemical called serotonin in the brain which helps to improve your symptoms. Nice, right?

The science of sertraline

Your brain naturally produces chemicals that make you feel good, like serotonin. Sertraline keeps neurons from reabsorbing this chemical so that you have more of it available in your brain. Long story short? For people with depression and anxiety disorders, this can help to improve their interest in activities or reduce their number of panic attacks.


Good to know

Potential sertraline side effects

The most common side effects of sertraline include feeling anxious, stuffy nose, dry mouth, trouble sleeping, dizziness, nausea, constipation, and joint aches. Less commonly, high blood pressure may manifest as a serious side effect. Talk to a health care professional about side effects, drug interactions, and any other questions you may have.


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Over 75% of Hers customers who checked in with their provider reported improvements in their mental health symptoms.*

* Results vary. Data were self-reported between 11/26/2021 and 08/01/2022 by Hers customers who 1) signed up between 11/04/2021 and 05/04/2022; 2) were prescribed antidepressant medication by a provider after their first consultation on the Hers platform; and 3) had an active subscription for such psychiatric medication through the Hers platform within 90 days after signing up.

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Frequently asked questions about sertraline

How long does it take for sertraline to work for depression or anxiety?

Sertraline was shown to be effective as a treatment for major depressive disorder and other anxiety-related disorders in clinical trials lasting 6-12 weeks. Consult with your healthcare provider if you do not think your condition is getting better.

How does sertraline make you feel?

Sertraline has been shown to be effective in treating depression and anxiety symptoms. Even if you start to feel better, do not stop taking your medication without first talking to your healthcare provider.

What are potential side effects of sertraline?

Serious side effects may include seizures, low sodium levels, angle closure glaucoma, teeth grinding, serotonin syndrom, increased risk of bleeding when mixed with an NSAID and allergic reaction.
Other adverse effects of sertraline may include weight gain or loss, nausea, upset stomach, sexual dysfunction or problems with ejaculation, sleeping problems, dizziness, fatigue and more.
As always, seek guidance from your medical provider in the event of concerns about side effects.

What are some sertraline drug interactions?

Drugs such as the following may cause serious interactions with sertraline:
  • serotonergic medications
  • migraine medications
  • pain medications such as NSAIDs and aspirin
  • the antibiotic linezolid
  • warfarin or other anticoagulants
  • disulfiram
  • isocarboxazid
  • methylene blue
  • phenelzine
  • pimozide
  • tranylcypromine
This list is non-exhaustive. Talk to your healthcare provider before combining any medication with sertraline.

Learn more about sertraline

Important safety information

Learn more about sertraline

Important safety information

Important Safety Information

Do not take Sertraline if you:
  • are allergic to Sertraline, or any of the ingredients in Sertraline
  • take any medicines called monoamine oxidase inhibitor (MAOI), or if you have stopped taking an MAOI within the last 2 weeks
  • taking pimozide
  • are drinking alcohol
  • are using or abusing recreation drugs or prescription medications
Sertraline can cause serious side effects. Rarely reported side effects include:
  • low sodium blood levels (symptoms may include headache, weakness and difficulty remembering or concentrating)
  • teeth grinding
  • angle closure glaucoma (symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye)
  • serotonin syndrome (symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death)
  • seizure
  • increased risk of bleeding events when combined with use of aspirin, nonsteroidal anti-inflammatory drugs (e.g. ibuprofen, naproxen), warfarin, and other anticoagulants
Before you take Sertraline, tell your healthcare provider if you:
  • have thoughts of suicide or harming yourself
  • have a history of psychiatric or medical problems, including bipolar disorder
  • have taken any medication in the past for your condition, whether effective or not
  • have suffered adverse or side effects from previous medication therapies
  • are receiving any non-medication treatment, such as talk therapy
  • drink alcohol or use/abuse recreational or prescription drugs
  • are pregnant, plan to become pregnant, or are breastfeeding
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements, and recreational drugs.
Sertraline may affect the way other medicines work, and other medicines may affect the way Sertraline works, causing side effects. Especially tell your healthcare provider if you take any of the following:
  • any other serotonergic medications, migraine medications (triptans), pain medications, antibiotic linezolid
  • aspirin, nonsteroidal anti-inflammatory drugs (e.g. ibuprofen, naproxen), warfarin, and other anticoagulants
  • disulfiram due to the alcohol content of the concentrate - if sertraline in liquid form
During treatment with this medication, the side effects of this medication may go away over the first week or two as your body adjusts to the medication. The most common side effects of Sertraline: Headache, nausea, diarrhea, dry mouth, increased sweating, feeling nervous, restless, fatigued, sleepy or having trouble sleeping (insomnia). Sexual side effects, such as problems with orgasm or ejaculatory delay often do not diminish over time.
Sertraline is a prescription medicine used to treat major depressive disorder (MDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder. (May also be helpful when prescribed “off-label” for binge-eating disorder, bulimia nervosa, and generalized anxiety disorder (GAD).)
If you miss a dose of sertraline, take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your healthcare provider. Do not double your next dose or take more than what is prescribed.
Do not stop taking sertraline, even when you feel better. Abruptly stopping can cause withdrawal symptoms including: irritability, nausea, feeling dizzy, vomiting, nightmares, headache, and/or paresthesias (prickling, tingling sensation on the skin).
Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.
Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient’s prescriber or healthcare professional. All patients being treated with antidepressants for any indication should watch for and notify their healthcare provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.
If needed, the best way to dispose of most types of old, unused, unwanted, or expired medicines (both prescription and over the counter) is to drop off the medicine at a drug take back site, location, or program immediately. You can use the DEA DIVERSION CONTROL DIVISION LOOKUP to find your nearest drug disposal site.
If you no longer need your medication, locations, or programs are available in your area, and there are no specific disposal instructions (such as flushing) in the medication guide or package insert, you can follow these simple steps to dispose of most medicines in your trash at home:
  • Mix medicines (liquid or pills; do not crush tablets or capsules) with an unappealing substance such as dirt, cat litter, or used coffee grounds;
  • Place the mixture in a container such as a sealed plastic bag;
  • Throw away the container in your trash at home; and
  • Delete all personal information on the prescription label of empty medicine bottles or medicine packaging, then trash or recycle the empty bottle or packaging.
If you're in emotional distress, text HOME to 741-741 to connect with a Crisis Text Line counselor immediately.
If you're having a medical or mental health emergency, call 911 or go to your local ER

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* Controlled substances, including amphetamines (such as Adderall) or benzodiazepines (such as Xanax and Valium) are not available through our platform.