FDA approved

Generic for Wellbutrin XL®Bupropion XL

Starting at $49/mo

Getting psychiatric care for anxiety and depression has never been more convenient. Consult with a healthcare provider through our platform to determine whether a medication like bupropion could be right for you.


  • Prescribed by a healthcare provider experienced in treating anxiety & depression, if appropriate
  • Unlimited provider messaging
  • Unlimited dosage adjustments

What is bupropion?

Bupropion is a special antidepressant in the NDRI family. Notably, bupropion was the first modern antidepressant medication on the market (ahead of Prozac®), first approved by the FDA in 1985 and later in 1989 as an extended-release (XL) formula. Bupropion is sold under the brand names Wellbutrin®, Wellbutrin XL®, Wellbutrin SR®, Aplenzin®, and Zyban®.

Bupropion uses

Bupropion is approved by the FDA for the treatment of major depressive disorder (MDD), seasonal affective disorder, and smoking cessation (in combination with nicotine replacement therapy).

How bupropion works

Bupropion is an NDRI and affects the balance of neurotransmitter chemicals in the brain, specifically norepinephrine and dopamine. This can ease symptoms of depression.

* Only available if prescribed after an online consultation with a healthcare provider.

* Controlled substances such as Xanax and Adderall are not available through our platform.

* This page has been medically reviewed by Sylvia Valadez, MSN, APRN, FNP-BC.

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Bupropion XL Generic for Wellbutrin XL®

How to get bupropion online with Hers

1. Simple consultation

Complete an online mental health assessment and intake form, then connect with a healthcare provider through our platform.

2. Free delivery

Get bupropion shipped to you for free, if prescribed.

3. Ongoing support

Enjoy secure, ongoing support 100% online—including refills and unlimited dosage adjustments.

What’s an NDRI?

Norepinephrine and dopamine reuptake inhibitors (NDRIs) zero in on mood-affecting chemicals in the brain and help to regulate their levels to improve your symptoms. Nice, right?

The science of bupropion

Your brain naturally produces chemicals that make you feel good, like norepinephrine and dopamine. Bupropion keeps neurons from reabsorbing these chemicals so that you have more of them available in your brain. Long story short? This can help relieve symptoms of depression.


Things to know

Serious bupropion side effects

Serious adverse effects could include suicidal thoughts, anxiety, eye pain, instances of manic behavior, risk of seizures or seizure disorder in patients with eating disorders such as bulimia or anorexia, irregular heartbeat, and high blood pressure. Seek immediate medical advice from a healthcare professional if you experience these serious side effects.


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Felt better

Over 75% of Hers customers who checked in with their provider reported improvements in their mental health symptoms.*

* Results vary. Data were self-reported between 11/26/2021 and 08/01/2022 by Hers customers who 1) signed up between 11/04/2021 and 05/04/2022; 2) were prescribed antidepressant medication by a provider after their first consultation on the Hers platform; and 3) had an active subscription for such psychiatric medication through the Hers platform within 90 days after signing up.

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Before they're accepted to the pool of professionals we work with, all healthcare providers undergo a rigorous vetting process. They have years of experience and they’re ready to help with whatever you’re going through.

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Frequently asked questions about bupropion

Does bupropion help with anxiety?

Bupropion (generic for Wellbutrin®) is not indicated or FDA-approved for the treatment of anxiety. In fact, anxiety is listed as a potential side effect of bupropion.

Does bupropion (generic for Wellbutrin®) work immediately?

The immediate-release formulation of bupropion was shown to be effective in treating symptoms of depression in clinical trials lasting 4-6 weeks.

What are the common side effects of bupropion?

The most common side effects when taking bupropion are headache, dizziness, dry mouth, loss of appetite, weight loss, mild diarrhea, constipation, nausea, vomiting, sleepiness or trouble sleeping.

Are there any off-label uses for bupropion?

Certain doses of bupropion are sometimes prescribed to treat attention deficit hyperactivity disorder (ADHD), sexual dysfunction caused by antidepressants, and depression related to bipolar disorder. The Food and Drug Administration has not approved these treatments.

Does bupropion cause weight gain?

Bupropion does not typically cause weight gain. In fact, many users lose weight when taking the medication and weight loss is a documented side effect of bupropion.

Can I get bupropion online?

Yes. Through the hers online psychiatry platform, you may be prescribed bupropion, if appropriate.

Learn more about bupropion

Important safety information

Learn more about bupropion

Important safety information

Important Safety Information

Do not take Bupropion XL (bupropion hydrochloride) if you:
  • are allergic to Bupropion, as contained in bupropion hydrochloride, or any of the ingredients in Bupropion
  • take any medicines called monoamine oxidase inhibitor (MAOI), or if you have stopped taking an MAOI in the last 14 days
  • are already taking a medication containing bupropion
  • taking tamoxifen
  • have a medical history of a seizure disorder, anorexia nervosa, or bulimia nervosa
  • drink large amounts of alcohol, use recreational drugs or abuse prescription medications - or suddenly stop substance abuse habits
Bupropion can cause serious side effects. Rarely reported side effects include:
  • Confusion
  • Fainting
  • Seizures
  • Inability to concentrate
  • Auditory or visual hallucinations
  • Paranoia
Before you take Bupropion, tell your healthcare provider if you:
  • have thoughts of suicide or harming yourself
  • have a history of psychiatric or medical problems, including bipolar disorder
  • have taken any medication in the past for your condition, whether effective or not
  • have suffered adverse or side effects from previous medication therapies
  • are receiving any non-medication treatment, such as talk therapy
  • are pregnant, plan to become pregnant, or are breastfeeding
  • drink alcohol or use/abuse recreational or prescription drugs
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements, and recreational drugs.
Bupropion may affect the way other medicines work, and other medicines may affect the way Bupropion works, causing side effects. Especially tell your healthcare provider if you take any of the following:
  • take any medicines called monoamine oxidase inhibitor (MAOI), or if you have stopped taking and MAOI in the last 14 days
During treatment with this medication, the side effects of this medication may go away as your body adjusts to the medication. The most common side effects of Bupropion: constipation, decrease in appetite, dizziness, increased sweating, stomach pain, trembling, and unusual weight loss.
Bupropion (bupropion hydrochloride) is a prescription medicine used to treat major depressive disorder (MDD), seasonal affective disorder (SAD), and to help people quit smoking (smoking cessation). (May also be helpful when prescribed “off-label” for bipolar disorder, attention deficit hyperactivity disorder (ADHD, and sexual dysfunction due to SSRI antidepressants.)
Swallow the tablet whole. Do not break, crush or chew it.
If you miss a dose of this medicine, for the XL form, do not take an extra tablet to make up for the dose you forgot. Wait and take your next dose at your regular time the next day. Do not double doses.
Do not stop taking bupropion or change your dose without talking with your healthcare provider first.
While depressed mood and lack of interest in activities may need up to 4-6 weeks to improve, disturbances in sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working.
Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient’s prescriber or healthcare professional. All patients being treated with antidepressants for any indication should watch for and notify their healthcare provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.
If you no longer need your medication, the best way to dispose of most types of old, unused, unwanted, or expired medicines (both prescription and over the counter) is to drop off the medicine at a drug take back site, location, or program immediately. You can use the DEA DIVERSION CONTROL DIVISION LOOKUP to find your nearest drug disposal site.
If no drug take back sites, locations, or programs are available in your area, and there are no specific disposal instructions (such as flushing) in the medication guide or package insert, you can follow these simple steps to dispose of most medicines in your trash at home:
  • Mix medicines (liquid or pills; do not crush tablets or capsules) with an unappealing substance such as dirt, cat litter, or used coffee grounds;
  • Place the mixture in a container such as a sealed plastic bag;
  • Throw away the container in your trash at home; and
  • Delete all personal information on the prescription label of empty medicine bottles or medicine packaging, then trash or recycle the empty bottle or packaging.
If you're in emotional distress, text HOME to 741-741 to connect with a Crisis Text Line counselor immediately.
If you're having a medical or mental health emergency, call 911 or go to your local ER

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* Controlled substances, including amphetamines (such as Adderall) or benzodiazepines (such as Xanax and Valium) are not available through our platform.