The Sexual Side Effects of Cymbalta

Kristin Hall

Reviewed by Kristin Hall, FNP

Written by Geoffrey C. Whittaker

Published 08/02/2022

Updated 08/03/2022

Cymbalta® is an effective medication for several psychiatric disorders and mood disorders, and for many people, it drastically improves quality of life. But if you’re one of the people who Cymbalta side effects sexually affect, you may beg to differ.

The sexual side effects of Cymbalta might be something you read about in a pamphlet or saw mentioned in a television commercial. If you have a great healthcare provider, they may even have mentioned that sexual dysfunction is a risk for some people taking this medication. But many people never see these side effects — and some people may not really notice changes. 

You, on the other hand, may. And if you’re already struggling with low libido, decreased sexual desire or another sexual issue, it’s understandable that you’d want to know if, how and why the sexual side effects of Cymbalta might change your quality of life. 

Cymbalta can be great for many depression sufferers, but if you’re worried about sexual side effects that might be a dealbreaker, here’s what you need to know.

Cymbalta, also known as duloxetine (its generic form) is an antidepressant treatment that helps your brain level out mood imbalances and treat the symptoms of depression. It does this primarily by affecting your brain’s supply of certain neurotransmitters. 

Many antidepressant medications work this way, and they can affect serotonin levels (which affect your moods), norepinephrine levels (which regulate stress) or even dopamine levels (which regulate pleasure).

Cymbalta is a serotonin and norepinephrine reuptake inhibitor or SNRI, which regulates both serotonin and norepinephrine to help people with anxiety disorders and depressive disorders live better lives.

These prescription medications can cause side effects — headaches, nausea, fatigue and irritability can be common symptoms of the medication having an adverse effect on you. 

online mental health assessment

your mental health journey starts here

Okay, but what about your sex drive? Is Cymbalta going to crush your desire for sex or make sexual intercourse impractical? Unfortunately, the answer to that one is: possibly.

Cymbalta can absolutely affect your sex drive. In fact, it can affect a lot of the main functions of your sex life.

Cymbalta can cause sexual side effects for both men and women, and they’re generally very similar — reduced sex drive or reduced libido, mainly.

Antidepressant-associated sexual dysfunction can mean several symptoms. 

Men can experience problems with ejaculatory dysfunction, erectile dysfunction and problems maintaining an erection. 

For women, the problems will appear as orgasmic dysfunction or a difficulty with reaching orgasm. 

These problems can make it difficult to enjoy or even perform in intimate situations, and over time, that could potentially erode your connection and sense of intimacy with your partner.

While the sexual symptoms of Cymbalta aren’t life-threatening, that’s no less of a reason to take them seriously if your quality of life is being affected.

If that’s the case, it might be time to do something about it.

There are two important answers to the question of whether you should stop taking Cymbalta.

The first is whether or not it’s a good idea to stop taking your anti-depression medication. Generally speaking, it’s not a good idea to abruptly stop taking antidepressant drugs without consulting your healthcare provider for guidance.

Ceasing a course of antidepressant medication can cause noticeable side effects, a relapse of depressive disorder and increased risk of suicidality. 

And, depending on how much medication you were taking and whether you wean yourself off of it, you could be setting yourself up for some extremes.

In most cases, a health care provider will wean you slowly off of a medication that is no longer promoting your mental health goals. This will be done to ensure your safety and help your brain adjust more gradually to not having medication for support anymore.

The second, larger question, however, is whether you should go off of Cymbalta at all. This is a conversation you’ll have to have independently with a healthcare provider. 

Together, you’ll weigh the pros and cons of stopping or changing this medication and arrive at the best course of action for your individual needs.

You may end up using more effective antidepressants like tricyclic antidepressants or the popular effects of SSRIs to combat your depressive symptoms.

Whether Cymbalta is part of your treatment for depression or not is ultimately a conversation you’ll need to have with a medical professional. 

If your common side effects are overwhelming, it may be smart to move to a different medication or even an alternative therapy like, well, therapy. This is where hers’ online counseling may be of help.

psych meds online

psychiatrist-backed care, all from your couch

Antidepressant-induced sexual dysfunction in some depressed patients may be a worthy price to pay if you’re overwhelmed by major depression, severe depression or another depressive illness, but that is ultimately a decision for you to make with the help of your healthcare provider.

Treating depression can sometimes mean making mild side effects a necessary evil, but there’s a fine balance to be struck between what you tolerate for your mental health and what does net harm to it. 

What we’re getting at here is, if a healthy sex life and intimacy are priorities for you right now, these may be more important concerns to mention to a health care provider before taking a new medication or once side effects have begun to appear. 

This is a great time to remind you that just because a medication is “working” doesn’t mean it’s the “right” medication for you. Potential side effects that reduce your quality of life aren’t side effects: they’re effects. 

If you’re navigating the uncharted waters of treatment for depression alone or without talking to healthcare professionals, these questions and uncertainties can put you in danger — so don’t wait to involve someone else in the conversation. 

1 Source

Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references.

  1. U.S. National Library of Medicine. (n.d.). Duloxetine: Medlineplus drug information. MedlinePlus. Retrieved June 5, 2022, from

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standards here.

Kristin Hall, FNP

Kristin Hall is a board-certified Family Nurse Practitioner with decades of experience in clinical practice and leadership. 

She has an extensive background in Family Medicine as both a front-line healthcare provider and clinical leader through her work as a primary care provider, retail health clinician and as Principal Investigator with the NIH

Certified through the American Nurses Credentialing Center, she brings her expertise in Family Medicine into your home by helping people improve their health and actively participate in their own healthcare. 

Kristin is a St. Louis native and earned her master’s degree in Nursing from St. Louis University, and is also a member of the American Academy of Nurse Practitioners. You can find Kristin on LinkedIn for more information.

Read more

Care for your mind,
care for your self

Start your mental wellness journey today.