FDA approved

Generic for Cymbalta®Duloxetine

Starting at $49/mo

Getting psychiatric care for anxiety and depression has never been more convenient. Consult with a healthcare provider through our platform to determine whether a medication like duloxetine could be right for you.


  • Prescribed by a healthcare provider experienced in treating anxiety & depression, if appropriate
  • Unlimited provider messaging
  • Free dosage adjustments

What is duloxetine?

Duloxetine is an antidepressant, specifically an SNRI (serotonin-norepinephrine reuptake inhibitor). Duloxetine was first approved by the FDA in 2004 and sold under the brand names Cymbalta and others.

Duloxetine uses

Duloxetine is FDA approved to treat generalized anxiety disorder (GAD) and major depressive disorder (MDD). It is also indicated for certain other conditions related to nerve pain including diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain. Treatment for nerve pain is not available through our platform. Those seeking care for nerve pain should consider seeing a medical provider outside our platform to evaluate potential options for treatment.

How duloxetine works

Duloxetine is an SNRI and works by discouraging nerves in the brain (neurons) from absorbing two substances, serotonin and norepinephrine, thereby increasing their levels in the brain. This can have beneficial effects on psychiatric disorders, such as anxiety and depression.

* Only available if prescribed after an online consultation with a healthcare provider.

* Controlled substances such as Xanax and Adderall are not available through our platform.

* This page has been medically reviewed by Sylvia Valadez, MSN, APRN, FNP-BC.

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Duloxetine Generic for Cymbalta®

How to get duloxetine online with Hers

1. Simple consultation

Complete an online mental health assessment and intake form, then connect with a healthcare provider through our platform.

2. Free delivery

Get duloxetine shipped to you for free, if prescribed.

3. Ongoing support

Enjoy secure, ongoing support 100% online—including refills and unlimited dosage adjustments.

What’s an SNRI?

Serotonin-norepinephrine reuptake inhibitors (SNRIs) zero in on mood-affecting chemicals in the brain and help to regulate their levels to improve your symptoms. Nice, right?

The science of duloxetine

Your brain naturally produces chemicals that make you feel good, like serotonin and norepinephrine. Duloxetine keeps neurons from reabsorbing these chemicals so that you have more of them available in your brain. Long story short? This can help relieve symptoms of anxiety and depression.


Good to know

Potential duloxetine side effects

The most common side effects of duloxetine include nausea, dry mouth, sleepiness, fatigue, constipation, loss of appetite, dizziness, and increased sweating. Duloxetine can affect blood pressure, which should be monitored. Discuss any side effects you experience with your provider.


Felt better

Over 75% of Hers customers who checked in with their provider reported improvements in their mental health symptoms.*

* Results vary. Data were self-reported between 11/26/2021 and 08/01/2022 by Hers customers who 1) signed up between 11/04/2021 and 05/04/2022; 2) were prescribed antidepressant medication by a provider after their first consultation on the Hers platform; and 3) had an active subscription for such psychiatric medication through the Hers platform within 90 days after signing up.

You’re in good hands.

Before they're accepted to the pool of professionals we work with, all healthcare providers undergo a rigorous vetting process. They have years of experience and they’re ready to help with whatever you’re going through.

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Frequently asked questions about duloxetine

How does duloxetine (generic for Cymbalta®) make you feel?

When taken as prescribed, duloxetine has been shown to treat symptoms of anxiety and depression. Notably, studies show duloxetine has an analgesic effect on painful physical symptoms of MDD, and this effect is partially independent of improvement in MDD.

How long does it take for duloxetine (generic for Cymbalta®) to work?

Duloxetine was shown to be effective as a treatment for anxiety and depression in clinical trials lasting 8-10 weeks. Consult with your healthcare provider if you do not think your condition is getting better.

Does duloxetine (generic for Cymbalta®) cause weight gain?

According to one study in JAMA Psychiatry, duloxetine was associated with a slight increase in weight after initial prescription. However, this increase was approximately 1% of body weight over 12 months, which was less than other antidepressant medication options.

Does duloxetine (generic for Cymbalta®) help with anxiety?

Duloxetine is FDA-approved to treat generalized anxiety disorder. However, duloxetine is not for people who experience occasional anxiety caused by normal life events.

Who should not take duloxetine (generic for Cymbalta)?

You should not take duloxetine or Cymbalta if you have uncontrolled narrow-angle glaucoma or have taken an MAOI in the past 14 days. Additionally, you should not take duloxetine with nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen.

What are the serious side effects of duloxetine (generic for Cymbalta)?

Serious adverse effects of Cymbalta may include:
  • liver damage or failure
  • vision problems
  • Stevens-Johnson syndrome (rash with flu-like symptoms)
  • serotonin syndrome
  • difficulty urinating
  • increased risk of bleeding

Can I buy duloxetine online?

If appropriate, a licensed provider on the hers platform can prescribe duloxetine for you. Start a free psychiatry consultation to find out if you qualify for treatment.

Learn more about duloxetine

Important safety information

Learn more about duloxetine

Important safety information

If you're in emotional distress, text HOME to 741-741 to connect with a Crisis Text Line counselor immediately.
If you're having a medical or mental health emergency, call 911 or go to your local ER

* Controlled substances, including amphetamines (such as Adderall) or benzodiazepines (such as Xanax and Valium) are not available through our platform.