FDA approved

DuloxetineGeneric for Cymbalta®

Getting psychiatric care for anxiety and depression has never been more convenient. Consult with a healthcare provider through our platform to determine whether a medication like duloxetine could be right for you.

Details

  • Prescribed by a healthcare provider experienced in treating anxiety & depression, if appropriate
  • Unlimited provider messaging
  • Free dosage adjustments

What is duloxetine?

Duloxetine is an antidepressant, specifically an SNRI (serotonin-norepinephrine reuptake inhibitor). Duloxetine was first approved by the FDA in 2004 and sold under the brand names Cymbalta and others. Duloxetine was first approved by the FDA in 2004 and sold under the brand names Cymbalta® and others.

Duloxetine uses

Duloxetine is FDA approved to treat generalized anxiety disorder (GAD) and major depressive disorder (MDD). It is also indicated for certain other conditions related to nerve pain including diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain. Treatment for nerve pain is not available through our platform. Those seeking care for nerve pain should consider seeing a medical provider outside our platform to evaluate potential options for treatment.

How duloxetine works

Duloxetine is an SNRI and works by discouraging nerves in the brain (neurons) from absorbing two substances, serotonin and norepinephrine, thereby increasing their levels in the brain. This can have beneficial effects on psychiatric disorders, such as anxiety and depression.

* Only available if prescribed after an online consultation with a healthcare provider.

* This page has been medically reviewed by Sylvia Valadez, MSN, APRN, FNP-BC.

Select your plan

Duloxetine Generic for Cymbalta®

How to get duloxetine online with Hers

1. Simple consultation

Complete an online mental health assessment and intake form, then connect with a healthcare provider through our platform.

2. Free delivery

Get duloxetine shipped to you for free, if prescribed.

3. Ongoing support

Enjoy secure, ongoing support 100% online—including refills and free dosage adjustments.


What’s an SNRI?

Serotonin-norepinephrine reuptake inhibitors (SNRIs) zero in on mood-affecting chemicals in the brain and help to regulate their levels to improve your symptoms. Nice, right?

The science of duloxetine

Your brain naturally produces chemicals that make you feel good, like serotonin and norepinephrine. Duloxetine keeps neurons from reabsorbing these chemicals so that you have more of them available in your brain. Long story short? This can help relieve symptoms of anxiety and depression.

Duloxetine

Duloxetine (generic for Cymbalta®)

Potential side effects

The most common side effects of duloxetine include nausea, dry mouth, sleepiness, fatigue, constipation, loss of appetite, dizziness, and increased sweating. Duloxetine can affect blood pressure, which should be monitored. Discuss any side effects you experience with your provider.

Duloxetine

Real results from women like you

Gabriela

“With Hims & Hers I paid 3x less for appointment & medication, with the certainty of a trustful and professional service.”

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Ilyssa

“I got the help I needed, from the comfort of my couch...If you are struggling, Hers is the perfect place to begin your mental wellness journey.”
 

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Andrea

“It was easier and more affordable than I ever imagined to get my medication.”

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Candace

“Since my session I have still experienced some anxiety, but I feel like I am able to handle it and calm myself down now.”

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Taysha

“I have been subscribed for 6 months and I can honestly say I’m doing so much better.”

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*Customers who provided testimonials received free product.

You can feel like


yourself

 

again.

Over 80% of Hers mental health customers see improvement in their symptoms through treatment.

*based on a survey of 2,000 Hims & Hers customers who received treatment for anxiety or depression through our platform

You can feel like


yourself

 

again

Over 80% of Hers mental health customers see improvement in their symptoms through treatment.

*based on a survey of 2,000 Hims & Hers customers who received treatment for anxiety or depression through our platform

You’re in good hands.

Before they're accepted to the pool of professionals we work with, all healthcare providers undergo a rigorous vetting process. They have years of experience and they’re ready to help with whatever you’re going through.

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Frequently asked questions about duloxetine

How does duloxetine (generic for Cymbalta®) make you feel?

When taken as prescribed, duloxetine has been shown to treat symptoms of anxiety and depression. Notably, studies show duloxetine has an analgesic effect on painful physical symptoms of MDD, and this effect is partially independent of improvement in MDD.

How long does it take for duloxetine (generic for Cymbalta®) to work?

Duloxetine was shown to be effective as a treatment for anxiety and depression in clinical trials lasting 8-10 weeks. Consult with your healthcare provider if you do not think your condition is getting better.

Does duloxetine (generic for Cymbalta®) cause weight gain?

According to one study in JAMA Psychiatry, duloxetine was associated with a slight increase in weight after initial prescription. However, this increase was approximately 1% of body weight over 12 months, which was less than other antidepressant medication options.

Does duloxetine (generic for Cymbalta®) help with anxiety?

Duloxetine is FDA-approved to treat generalized anxiety disorder. However, duloxetine is not for people who experience occasional anxiety caused by normal life events.

Learn more about duloxetine

Important safety information

Learn more about duloxetine

Important safety information

Important Safety Information

Do not take Duloxetine if you:
  • are allergic to Duloxetine, or any of the ingredients in Duloxetine
  • take any medicines called monoamine oxidase inhibitor (MAOI), or if you have stopped taking an MAOI in the last 14 days
  • have a medical history of a liver disease
  • are drinking alcohol
  • are using or abusing recreation drugs or prescription medications
Duloxetine can cause serious side effects. Rarely reported side effects include:
  • liver failure, sometimes fatal
  • orthostatic hypotension,a drop in blood pressure when standing or getting up from sleep
  • increased risk of bleeding
  • increased heart rate
  • irregular menstrual cycle
  • frequency of urination or difficulty urinating
  • angle closure glaucoma (symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye)
  • serotonin syndrome (symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death)
  • hypertensive crisis
  • Stevens-Johnson Syndrome (rash)
  • pancreatitis
Before you take Duloxetine, tell your healthcare provider if you:
  • have thoughts of suicide or harming yourself
  • have a history of psychiatric or medical problems, including bipolar disorder
  • have taken any medication in the past for your condition, whether effective or not
  • have suffered adverse or side effects from previous medication therapies
  • are receiving any non-medication treatment, such as talk therapy
  • drink alcohol or use/abuse recreational or prescription drugs
  • are pregnant, plan to become pregnant, or are breastfeeding
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements, and recreational drugs.
Duloxetine may affect the way other medicines work, and other medicines may affect the way Duloxetine works, causing side effects. Especially tell your healthcare provider if you take any of the following:
  • any other serotonergic medications, migraine medications (triptans), pain medications, antibiotic linezolid, amphetamines
  • anticoagulant therapy
  • cimetidine (Tagamet®)
  • ciprofloxacin (Cipro®)
During treatment with this medication, the side effects of this medication may go away as your body adjusts to the medication. The most common side effects of Duloxetine: headache, nausea, diarrhea, dry mouth, constipation, increased sweating, feeling nervous, restless, fatigued, sleepy or having trouble sleeping (insomnia). Sexual side effects (such as problems with orgasm or ejaculatory delay) or increased blood pressure. These often do not improve over time.
Duloxetine is a prescription medicine used to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), diabetic peripheral neuropathic pain (DPNP), fibromyalgia, and chronic musculoskeletal pain.
Swallow the capsule whole. Do not break, crush or chew it. If you miss a dose of duloxetine take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your healthcare provider. Do not double your next dose or take more than what is prescribed.
Do not abruptly stop taking Duloxetine even when you feel better. Abruptly stopping can cause withdrawal symptoms including: vomiting, irritability, dizziness, headaches, sensation of tingling skin, or nightmares.
Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.
Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient’s prescriber or healthcare professional. All patients being treated with antidepressants for any indication should watch for and notify their healthcare provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.
If you no longer need your medication, the best way to dispose of most types of old, unused, unwanted, or expired medicines (both prescription and over the counter) is to drop off the medicine at a drug take back site, location, or program immediately. You can use the DEA DIVERSION CONTROL DIVISION LOOKUP to find your nearest drug disposal site.
If no drug take back sites, locations, or programs are available in your area, and there are no specific disposal instructions (such as flushing) in the medication guide or package insert, you can follow these simple steps to dispose of most medicines in your trash at home:
  • Mix medicines (liquid or pills; do not crush tablets or capsules) with an unappealing substance such as dirt, cat litter, or used coffee grounds;
  • Place the mixture in a container such as a sealed plastic bag;
  • Throw away the container in your trash at home; and
  • Delete all personal information on the prescription label of empty medicine bottles or medicine packaging, then trash or recycle the empty bottle or packaging.
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