Compare common side effects, interactions, warnings, and more.
Bupropion
Trintellix
*image for illustrative purpose only
Bupropion is the active ingredient in the brand-name medication Wellbutrin SR®. The information below is about brand name Wellbutrin SR. According to the FDA, “Generic medicines use the same active ingredients as brand-name medicines and work the same way, so they have the same risks and benefits as the brand-name medicines.”
Wellbutrin SR (bupropion sustained-release) is an antidepressant that works by inhibiting the reuptake of norepinephrine and dopamine in the brain, which helps improve mood and reduce symptoms of depression. Its FDA-approved indication includes the treatment of major depressive disorder (MDD). Off-label uses may include smoking cessation, anxiety, and attention-deficit hyperactivity disorder (ADHD). Wellbutrin SR is available in sustained-release tablet form, typically taken once or twice daily. Common side effects include insomnia, dry mouth, constipation, and headache, and it has a boxed warning for an increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults during the initial stages of treatment.
Trintellix® (vortioxetine) is an antidepressant used to treat major depressive disorder (MDD) by increasing serotonin activity in the brain through multiple mechanisms, including serotonin reuptake inhibition and modulation of various serotonin receptors. Its FDA-approved indication is for the treatment of major depressive disorder in adults. Trintellix is available in tablet form, typically taken once daily. Common side effects include nausea, constipation, and vomiting, while serious risks include serotonin syndrome when taken with other serotonergic drugs. There is an increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults during the initial treatment period.
Aminoketone antidepressant
Atypical antidepressant
Wellbutrin SR (bupropion hydrochloride) is indicated:
For the treatment of major depressive disorder (MDD)
Trintellix (vortioxetine) is indicated:
For the treatment of major depressive disorder (MDD) in adults
Typically taken orally twice daily
Comes in 100 mg, 150 mg, and 200 mg tablets
Typically taken orally once daily
Comes in 5 mg, 10 mg, and 20 mg tablets
Most common adverse reactions (incidence ≥5% and ≥2% more than placebo rate) are:
Headache
Dry mouth
Nausea
Insomnia
Dizziness
Inflammation of the throat
Constipation
Agitation
Anxiety
Abdominal pain
Ringing in the ears
Tremor
Fluttering heartbeat
Muscle pain
Sweating
Rash
Anorexia
Most common adverse reactions (incidence ≥5% and at least twice the rate of placebo) were:
Nausea
Constipation
Vomiting
Seizure disorder
Current or prior diagnosis of bulimia or anorexia nervosa
Abrupt discontinuation of alcohol, benzodiazepines, barbiturates, antiepileptic drugs
Monoamine oxidase inhibitors (MAOIs)
Known hypersensitivity to bupropion or other ingredients of Wellbutrin SR.
Drug interactions: CYP2B6 inducers, drugs metabolized by CYP2D6, digoxin, drugs that lower seizure threshold, dopaminergic drugs (levodopa and amantadine), MAOIs
Drug-laboratory test interactions: Wellbutrin SR can cause false-positive urine test results for amphetamines
Hypersensitivity to vortioxetine or any components of the Trintellix formulation
Monoamine oxidase inhibitors (MAOIs)
Drug interactions: strong inhibitors of CYP2D6, strong CYP Inducers
Neuropsychiatric adverse events during smoking cessation
Seizure risk
High blood pressure
Activation of mania/hypomania
Psychosis and other neuropsychiatric reactions
Angle-closure glaucoma
Serotonin syndrome
Increased risk of bleeding
Activation of mania/hypomania: Screen patients for bipolar disorder.
Angle closure glaucoma
Low blood sodium: Can occur in association with the syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Sexual dysfunction
Pregnancy: Third trimester use may increase risk for persistent pulmonary hypertension and withdrawal in the newborn
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS
Increased risk of suicidal thinking and behavior in children, adolescents and young adults taking antidepressants.
Monitor for worsening and emergence of suicidal thoughts and behaviors.
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS
Increased risk of suicidal thinking and behavior in pediatric and young adult patients taking antidepressants.
Closely monitor for worsening and emergence of suicidal thoughts and behaviors.
Trintellix is not approved for use in pediatric patients.
*This information is from the label for brand name Wellbutrin SR®. See the Full Prescribing Information for more complete information. Bupropion, the active ingredient in Wellbutrin XL, may also be the active ingredient in other medications, and this information may not be accurate for all medications that include the active ingredient bupropion.
*This information is from the label for brand name Trintellix®. See the Full Prescribing Information for more complete information.
The information provided here is NOT MEDICAL ADVICE and is for informational and educational purposes only. The drug comparison tool does not determine eligibility for medications or treatments provided via the Hims/Hers platform. Consultation with a healthcare provider is required to assess suitability for any medical treatment based on individual health and medical history. All product names and associated trademarks are the property of their respective owners.