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Why Am I Not Losing Weight on Mounjaro?

Mike Bohl, MD, MPH, ALM

Reviewed by Mike Bohl, MD

Written by Corinne O'Keefe Osborn

Published 08/16/2024

Updated 08/15/2024

If you’ve been taking Mounjaro® (tirzepatide) and you’re not getting the weight loss results you want, you probably have questions. Is it that particular medication? Are you taking it correctly? Is there something else you should be doing differently?

Take a deep breath, and know that there are several reasonable explanations why you aren’t losing the weight you’d hoped to and plenty of solutions that can help support your weight loss journey.

Some examples: You may not be in a calorie deficit or you may have hit a weight loss plateau. Maybe you need a higher dose, want to try a different medication, or could adopt additional healthy habits to help you reach your goal. Keep reading to see what might be holding you back from hitting your weight loss goals — and what you can do about it.

“Results may vary” may feel like a part of every medication advertisement. That’s because individuals respond to drugs differently. Mounjaro and weight loss medications are no exception.

For context, Mounjaro is a brand name of the prescription medication tirzepatide, which is both a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. 

Tirzepatide helps control blood sugar and helps with weight loss by slowing down the time it takes for your stomach to empty so you feel fuller longer. The drug also works on the part of the brain that controls hunger and satiety by essentially tamping down your appetite. 

People on Mounjaro simply tend to eat less than they did before — an obvious, but important, factor for weight loss.

Mounjaro was approved by the Food & Drug Administration (FDA) to treat type 2 diabetes, but it’s sometimes prescribed off-label — for something that it’s not FDA approved for — to treat obesity and overweight. 

A 2024 study suggests that tirzepatide is generally safe and well-tolerated, while being an effective means of helping individuals lose weight and reduce their body mass index (BMI), a measure of healthy weight, overweight, and obesity.

Another version of tirzepatide called Zepbound® was FDA-approved to treat obesity. The drugs have the same active ingredient, tirzepatide. Both Mounjaro and Zepbound are injected just under the skin once a week.

If you aren’t losing weight on Mounjaro, you may achieve better results using a similar medication that works a little differently in the body. Some of those drugs include:

Some research suggests that Mounjaro may be more effective than Ozempic when it comes to weight loss in patients with type 2 diabetes.

If you aren’t getting the results you want with Mounjaro or you are experiencing side effects from that medication you’d rather avoid, talk with a healthcare provider about trying a different weight loss drug. 

Though these drugs all work in a similar way, the differences between them may make one more effective for you than another.

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Though Mounjaro and similar drugs are effective for most people who try them, it’s possible that you may be in the minority of individuals who simply don’t respond well.

It’s not clear why certain people don’t respond as well as others to these weight loss drugs. In some cases, a stronger dose or a different drug is the key. For others, more rigorously following healthy lifestyle habits is the answer. And for others, the solution to sustained weight loss must be found without weight loss medications.

A stronger dose of Mounjaro may have a more significant effect. A 2022 study of 475 adults with type 2 diabetes found that individuals who took 15 mg of tirzepatide lost almost twice as much weight as those who took weekly 5 mg doses. In the study, patients were also taking insulin glargine, and the primary endpoint being researched was blood sugar control.

Doctors typically start their patients on the lowest dose of prescription medications that they expect to be effective, hoping to minimize the risk of side effects or other complications. But if you are able to tolerate Mounjaro at a low dose and would like to see if a stronger dose boosts your weight loss efforts, talk with your doctor about adjusting your prescription.

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Weight loss treatment that puts you first

Mounjaro and weight loss medications aren’t cure-all solutions. Following a healthy eating program is a major factor in how successful you are on your weight loss journey. The medications may help suppress your appetite, but it’s critical that you adopt a balanced diet when you do eat.

A 2021 report on the most effective diets to support weight loss suggests that the most important factor is that you consume fewer calories than you use (as in, calorie deficit). The National Institutes of Health suggests trying to consume 500 fewer calories than you burn per day — a practice that may help you lose about a pound a week.

Researchers also recommend:

  • Eating a nutrient-rich and filling breakfast

  • Avoiding late-night snacking

  • Adopting a dietary strategy that you can maintain over the long-term 

Need some ideas? The Mediterranean diet emphasizes vegetables, fruits, whole grains, lean proteins, and healthy fats (such as olive oil), while discouraging foods with added sugars that offer an abundance of carbohydrates and calories without healthy nutrients.

Prioritizing lean protein is especially important for sustainable weight loss, as it makes you feel fuller longer and supports your efforts to sustain (and maybe even build) muscle mass while you lose body fat.

Just as it’s important to eat right while taking Mounjaro, it’s also helpful to boost your physical activity level in order to lose weight and keep it off. Regular exercise, including a mix of cardio and strength training, should help you lose weight and maintain your weight loss.

If you haven’t started a regular exercise program, try to pick activities that you enjoy and will stick with, even on those days you’re not especially motivated. Working out with a friend or accountability partner can help make exercise more fun and help you stick with it.

Are you not losing weight at all or are you not losing as much as you thought you would? It’s not uncommon for people using Mounjaro to lose a lot of weight early and then hit a weight loss plateau, where the pounds come off more slowly.

Be realistic about your weight loss journey and understand that changes in your body weight aren’t always predictable or consistent. Changes in your hormones and other factors may also slow down your weight loss progress. Additionally, if you go off Mounjaro, you may experience weight gain.

If you’re unsure about what your weight loss journey will or should look like, talk with your healthcare provider. The more you know about what to expect, the better you’ll handle the inevitable ups and downs of using Mounjaro and weight loss medications.

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Weight loss, unlocked

Mounjaro and weight loss drugs are usually effective for most people. But if you’re not losing weight on Mounjaro, you may need a higher dose, or you may need to make other adjustments. You could also try taking a different medication to help you reach your weight loss goals.

No matter what medication you’re on, you should couple the prescription with impactful lifestyle changes, like reducing your caloric intake, engaging in more physical activity, and other healthy behaviors, such as getting quality sleep and managing your stress.

As with all prescription medications, if you are unsatisfied with how Mounjaro is working (or not working), talk openly with your healthcare provider. You may need to learn more about the medication in order to have a realistic perspective on how you’re responding to Mounjaro and whether any changes are necessary.

Hers can help connect you with a medical professional so you can get a doctor-trusted treatment plan tailored to your needs and experiences.

6 Sources

  1. Cai W, et al. (2024). Tirzepatide as a novel effective and safe strategy for treating obesity: a systematic review of and meta-analysis of randomized controlled trials. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864442/
  2. Frias J, et al. (2021). Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. https://www.nejm.org/doi/full/10.1056/nejmoa2107519
  3. Jastreboff A, et al. (2022). Tirzepatide Once Weekly for the Treatment of Obesity. https://www.nejm.org/doi/full/10.1056/NEJMoa2206038
  4. Dahl D, et al. (2022). Effect of Subcutaneous Tirzepatide vs. Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients with Type 2 Diabetes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826179/
  5. Kim, J. (2021). Optimal Diet Strategies for Weight Loss and Weight Loss Maintenance. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017325/
  6. National Institutes of Health. (2022). Healthy weight control. https://newsinhealth.nih.gov/2022/12/healthy-weight-control
Editorial Standards

Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references. See a mistake? Let us know at [email protected]!

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standards here.

Mike Bohl, MD

Dr. Mike Bohl is a licensed physician and the Director of Medical Content & Authority at Hims & Hers. Prior to joining Hims & Hers, Dr. Bohl worked in digital health at Ro, focusing on patient education, and as the Director of Scientific & Medical Content at a stealth biotech PBC, working on pharmaceutical drug development. He has also worked in medical journalism for The Dr. Oz Show (receiving recognition for contributions from the National Academy of Television Arts and Sciences when the show won Outstanding Informative Talk Show at the 2016–2017 Daytime Emmy® Awards) and at Sharecare, and he is a Medical Expert Board Member at Eat This, Not That!.

Dr. Bohl obtained his Bachelor of Arts and Doctor of Medicine from Brown University, his Master of Business Administration and Master of Science in Healthcare Leadership from Cornell University, his Master of Public Health from Columbia University, and his Master of Liberal Arts in Extension Studies—Journalism from Harvard University. Dr. Bohl trained in internal medicine with a focus on community health at NYU Langone Health.

Dr. Bohl is Certified in Public Health by the National Board of Public Health Examiners, Medical Writer Certified by the American Medical Writers Association, a certified Editor in the Life Sciences by the Board of Editors in the Life Sciences, a Certified Personal Trainer and Certified Nutrition Coach by the National Academy of Sports Medicine, and a Board Certified Medical Affairs Specialist by the Accreditation Council for Medical Affairs. He has graduate certificates in Digital Storytelling and Marketing Management & Digital Strategy from Harvard Extension School and certificates in Business Law and Corporate Governance from Cornell Law School.

In addition to his written work, Dr. Bohl has experience creating medical segments for radio and producing patient education videos. He has also spent time conducting orthopaedic and biomaterial research at Case Western Reserve University and University Hospitals of Cleveland and practicing clinically as a general practitioner on international medical aid projects with Medical Ministry International.

Dr. Bohl lives in Manhattan and enjoys biking, resistance training, sailing, scuba diving, skiing, tennis, and traveling. You can find Dr. Bohl on LinkedIn for more information.

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