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Benzoyl peroxide topical

Benzoyl peroxide is a popular topical treatment for acne that helps kill bacteria and unclog pores, leading to clearer skin.

Medical Review byMike Bohl, MD, MBA, MPH, MS, ALMUpdated May 20, 2025

Medication Name

Benzoyl peroxide topical

*image for illustrative purpose only

Benzoyl peroxide topical

*image for illustrative purpose only

Basics

Topical benzoyl peroxide is a well-tolerated and effective acne treatment. It works by delivering oxygen into the pores, which helps kill the bacteria that leads to acne. It also helps unclog pores by gently exfoliating dead skin cells and reducing oil buildup. 

Benzoyl peroxide is available in various concentrations (typically 2.5% to 10%) and formulations, such as gels, creams, washes, and foams. It is advised to start with lower concentrations and gradually increase as tolerated. 

Benzoyl peroxide is often recommended for treating mild acne and may be used in combination with topical retinoids or antibiotics in cases of moderate-to-severe acne. It’s generally considered safe for long-term use, including during pregnancy, and results are often seen within four to six weeks of consistent use.

Common side effects include dryness, irritation, redness, and peeling, particularly when you first start using it. Daily use of non-comedogenic moisturizers and broad-spectrum sunscreen is advised in order to minimize irritation and protect the skin.

*Benzoyl Peroxide Topical Approved Uses

Benzoyl peroxide 10% is used:

  • For the treatment of acne

*Benzoyl Peroxide Topical Drug Category

Topical antibiotic

*Benzoyl Peroxide Topical Side Effects

Stop use and ask a doctor if:

  • Irritation becomes severe

Benzoyl Peroxide Topical Cost

The cost of benzoyl peroxide varies depending on factors such as the formulation and concentration of the product, the brand, and where you buy it. But it is a relatively inexpensive active ingredient available in a number of over-the-counter products. In general, over-the-counter products containing benzoyl peroxide may range in price from about $3 to $35.

How To Get Benzoyl Peroxide Topical

You can buy products that contain benzoyl peroxide over-the-counter at various pharmacies and online retailers. Some benzoyl peroxide products are only available via prescription from a healthcare provider; these products typically combine benzoyl peroxide with other active ingredients for managing acne, such as antibiotics or retinoids.

*Interactions & Contraindications

  • Do not use if you have sensitive skin

  • Do not use if you are sensitive to benzoyl peroxide

*Warnings & Precautions

  • Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If this occurs only use one topical acne medication at a time

  • Avoid unnecessary sun exposure and use a sunscreen

  • Avoid contact with the eyes, lips, and mouth

  • Avoid contact with hair and dyed fabrics which may be bleached by this product

  • Skin irritation may occur characterized by redness, burning, itching, peeling, or possibly swelling

  • Irritation may be reduced by using the product less frequently or in a lower concentration

  • If swallowed get medical help or contact a Poison Control Center right away

Benzoyl Peroxide Topical Alternatives

There are other medications prescribed to treat acne, some of which may be better suited to you than others. If you’re interested in finding an alternative to benzoyl peroxide, talk with your provider to learn more about other medications that may work well for you.

Other over-the-counter acne treatments may include one or more of the following active ingredients:

  • Alpha-hydroxy acids (AHAs), including glycolic acid and lactic acid

  • Azelaic acid

  • Retinol 

  • Salicylic acid 

Prescription acne treatment options include:

  • Clascoterone (Winlevi®)

  • Hormonal birth control pills, including Beyaz®, Ortho Tri-Cyclen®, and Yaz®

  • Oral retinoids such as isotretinoin (Absorica®

  • Other topical prescription retinoids, including tazarotene (Tazorac®) and tretinoin (Retin-A®)

  • Spironolactone (Aldactone®, CaroSpir®)

  • Topical medications that include salicylic acid or azelaic acid 

  • Topical or oral antibiotics, such as doxycycline, minocycline, or sarecycline

  • Combination medications

Medical procedures that may be used instead of or in addition to medications to help manage acne include:

  • Acne surgery

  • Chemical peels

  • Corticosteroid injections

  • Laser or light treatments

FAQs

Benzoyl peroxide has antibacterial and keratolytic effects on the skin. It helps kill the bacteria that contributes to acne both on the skin and within the hair follicles, and it also removes excess oil and dead skin cells, which helps keep pores free of clogs. In terms of side effects, benzoyl peroxide can cause skin irritation along with redness and dryness. 

Typically, you’ll notice results from using benzoyl peroxide within about four weeks, but it may take up to four months to see the full effects. Each person may respond differently to this medication, though.

Yes, benzoyl peroxide is generally considered safe for daily and long-term use, although you may find that using it every other day is enough to control your acne once your skin has cleared. If you stop using benzoyl peroxide, your acne may return. 

If the skin is broken, don’t use benzoyl peroxide. Using this medication on open skin can cause severe irritation.

References

*This information is from the benzoyl peroxide 10% gel label used by Axia Medical Solutions, LLC. See the full label for more complete information. Benzoyl peroxide may also be the active ingredient in other medications, and this information may not be accurate for all medications that include the active ingredient benzoyl peroxide.

  1. American Academy of Dermatology. (2024). Acne: diagnosis and treatment. https://www.aad.org/public/diseases/acne/derm-treat/treat 

  2. American Academy of Dermatology. (2023). Adult acne treatment dermatologists recommend. https://www.aad.org/public/diseases/acne/diy/adult-acne-treatment 

  3. Matin T, et al. (2024). Benzoyl peroxide. https://www.ncbi.nlm.nih.gov/books/NBK537220/ 

  4. NHS. (2022). Common questions about benzoyl peroxide. https://www.nhs.uk/medicines/benzoyl-peroxide/common-questions-about-benzoyl-peroxide/ 

  5. NHS. (2022). How and when to use benzoyl peroxide. https://www.nhs.uk/medicines/benzoyl-peroxide/how-and-when-to-use-benzoyl-peroxide/

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