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Heart health

Non-HDL Cholesterol

Also known as: Non-high-density lipoprotein cholesterol test, Non-HDL-C test, Atherogenic lipoprotein cholesterol test

A non-HDL cholesterol test measures the total amount of cholesterol in your blood that’s carried by “bad” lipoproteins — particles that can build up inside your arteries and increase the risk of heart disease. 

It’s calculated by subtracting your high-density lipoprotein cholesterol (HDL, the “good” cholesterol) from your total cholesterol, which includes low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and lipoprotein(a).

Non-HDL cholesterol gives a more complete picture of your risk for heart disease than LDL cholesterol alone. It is also convenient — unlike LDL, non-HDL cholesterol can be accurately measured without fasting.

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Key takeaways

  • Sample required: Blood

  • Tests for: All “bad” cholesterol in your blood that can contribute to atherosclerosis, or plaque buildup in your arteries.

  • Typical healthy range: Less than 130 milligrams per deciliter (mg/dL) for most people; lower targets may apply for people at higher risk of heart disease.

What can a non-HDL cholesterol test tell you?

A non-HDL-C test can help your provider better understand your: 

  • Total amount of “bad” cholesterol that can contribute to plaque buildup in your arteries

  • Risk for heart attack and stroke over time

  • Response to treatment, if you’re being treated for high cholesterol

Research indicates that non-HDL cholesterol levels better reflect total harmful cholesterol levels and the risk of heart disease than LDL cholesterol alone.

The Centers for Disease Control and Prevention recommends screening most healthy adults for high cholesterol, including non-HDL cholesterol, every four to six years. Many providers also check non-HDL levels more often if you’re being treated for high cholesterol, or if you have diabetes, obesity, or a family history of high cholesterol or heart problems.

What is being tested?

Non-HDL cholesterol represents the total amount of “bad” cholesterol, meaning the cholesterol that can lead to plaque formation in arteries. These include:

  • Low-density lipoprotein (LDL) – the primary “bad” cholesterol

  • Very-low-density lipoprotein (VLDL) – transports triglycerides and converts to LDL

  • Intermediate-density lipoprotein (IDL) – transitional particle between VLDL and LDL

  • Lipoprotein(a) – a genetically influenced lipoprotein linked to higher heart disease risk

  • Chylomicron remnants – leftover particles from dietary fat transport

Measuring non-HDL cholesterol provides a comprehensive snapshot of all potentially atherogenic (plaque-forming) lipoproteins.

Where is the non-HDL cholesterol test typically included?

Non-HDL cholesterol is automatically calculated as part of a lipid panel or advanced lipid panel. It does not require a separate order.

Non-HDL cholesterol testing is included as part of lab testing through Hers. Work with a provider to explore how to improve or optimize your health, and get recommendations to help you do both.

Who should get a non-HDL cholesterol test?

Most adults should have their cholesterol levels — including non-HDL cholesterol — checked at least once every four to six years, or more frequently if they have risk factors for heart disease.

Risk Factors for Elevated Non-HDL Cholesterol:

  • Family history of early heart disease

  • High blood pressure

  • Diabetes or metabolic syndrome

  • Smoking

  • Obesity or a sedentary lifestyle

  • A diet high in saturated fats

Providers may also order a lipid panel more often if you’re being treated for high cholesterol or heart disease.

Kids and teens with risk factors such as diabetes or obesity may also need regular screening.

How Labs by Hers works

  • 1

    Book your test

    Schedule a lab draw in the Hers app at one of more than 2,000 convenient locations.

  • 2

    Get your results

    Review your lab results to understand which areas of your health may need attention.

  • 3

    Spot early signals

    Identify potential health risks or system imbalances before they become more serious.

  • 4

    Get your action plan

    Receive expert guidance tailored to your health profile and test results.

  • 5

    Improve over time

    Track your progress through a mid-year panel and ongoing provider check-ins.

Not available in all 50 states. Eligibility and provider order required. Lab results alone are not intended to diagnose, treat, or cure any condition. A provider will reach out about critical results and plans include access to 24/7 provider messaging.

Images for illustrative purposes only.

Frequently asked questions

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What Causes Changes in Non-HDL Cholesterol?

Non-HDL cholesterol levels can change due to diet, lifestyle, and metabolic health. High non-HDL cholesterol often results from a diet high in saturated or trans fats, lack of exercise, excess weight, diabetes, insulin resistance, or genetic lipid disorders. It may also increase with kidney disease or hypothyroidism, which can alter lipid metabolism.

Low non-HDL cholesterol is less common and may occur with malnutrition, a very low-fat diet, chronic inflammatory conditions, or hyperthyroidism. Because non-HDL cholesterol reflects all “bad” cholesterol particles, changes can help indicate shifts in overall cardiovascular risk.

Is fasting required?

No. Non-HDL cholesterol is accurate regardless of fasting status.

How often should I test?

Every four to six years for healthy adults, or more often if you have risk factors for heart disease or are being treated for high cholesterol or heart disease.

How is non-HDL cholesterol different from LDL cholesterol?

LDL measures one form of “bad” cholesterol; non-HDL includes all harmful particles that contribute to plaque buildup, offering a more complete look at your risk for heart disease over time.

Can lifestyle changes lower non-HDL cholesterol?

Yes — weight loss, healthy eating, exercise, and smoking cessation can all significantly improve non-HDL cholesterol levels.

Does insurance cover this test?

Yes. Lipid panels, which include non-HDL cholesterol, are standard preventive screenings. Insurance is not required for lab testing available through the Hers platform.

What tests are related to this biomarker?

The information provided here is for informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always talk to a qualified healthcare provider about your specific health concerns.

Related biomarkers

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Apolipoprotein B

Apolipoprotein B (ApoB) is a protein that carries LDL and other bad cholesterol particles in the blood. Lower ApoB levels mean fewer harmful cholesterol particles are in your blood, and an overall reduced risk for heart disease.

Learn more about Apolipoprotein B

High-Sensitivity C-Reactive Protein

High-Sensitivity C-Reactive Protein (hs-CRP) is a liver-made protein that rises with inflammation. A low level is associated with a lower heart disease risk.

Learn more about High-Sensitivity C-Reactive Protein

Lipoprotein (a)

Lipoprotein (a), or Lp(a), is a genetically inherited cholesterol particle similar to LDL. A low level is a good sign for heart health.

Learn more about Lipoprotein (a)

HDL Cholesterol

HDL, or “good” cholesterol, acts like a cleanup crew to clear harmful fats from your blood. A healthy HDL level helps prevent buildup in your arteries.

Learn more about HDL Cholesterol

LDL Cholesterol

LDL is the “bad” cholesterol linked to plaque buildup in artery walls. A healthy level means fewer harmful cholesterol particles in your blood, which reduces overall risk for plaque buildup.

Learn more about LDL Cholesterol

Total Cholesterol

Total cholesterol is the total amount of all cholesterol types, including HDL, LDL, and other blood fats, and gives a general snapshot of your cholesterol status. When the number is in a good range, it shows a lower risk of developing heart disease.

Learn more about Total Cholesterol

Cholesterol/HDL Ratio

This ratio compares your total cholesterol to HDL, the "good" cholesterol.

Learn more about Cholesterol/HDL Ratio

Triglycerides

Triglycerides are a type of fat in your blood made from unused calories that are stored for energy. Low triglyceride levels indicate that your body is not having problems with insulin resistance or processing fat, which is good.

Learn more about Triglycerides

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Supporting references

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Reviewed by Darragh O'Carroll, MD

Published 12/04/2025