Labs by Hers: The key markers that matter. Start testing

Kidney health

Estimated Glomerular Filtration Rate

Also known as: Kidney function/filtration test (eGFR), Estimated GFR, Creatinine-based eGFR

The estimated glomerular filtration rate (eGFR) is a number used to assess how well your kidneys are filtering blood. It’s calculated using your creatinine (a waste product of muscle metabolism) levels combined with your age and sex.

Unlike measured GFR (which requires injected tracers and timed urine collection), eGFR provides a practical, widely available estimate of kidney function. It’s one of the most important tools for early detection and staging of chronic kidney disease (CKD).

Start testing
Learn more about Biomarkers

Key takeaways

  • Sample required: Blood

  • Tests for: Estimates how well your kidneys filter waste from your blood; central to detecting and staging chronic kidney disease (CKD).

  • Healthy range: ≥90 milliliters per minute (mL/min), but 60 to 89 mL/min can be normal in some adults (especially older adults) if there’s no other evidence of kidney damage.

What can an eGFR test tell you?

The eGFR indicates how effectively your kidneys are filtering blood. An eGFR above 90 mL/min usually reflects normal function, while 60 to 89 mL/min may still be normal (particularly with aging) if no other evidence of kidney damage is present. An eGFR lower than 60 that persists for three months or more typically signals chronic kidney disease, and an eGFR lower than 15 suggests kidney failure.

Clinicians use eGFR to stage CKD, monitor its progression over time, and guide medication dosing for drugs cleared by the kidneys.

What is being tested?

eGFR is a calculated value, not a direct lab measurement. The most widely used equations estimate GFR from your age, sex, and serum creatinine concentration.

Modern practice favors race‑free equations to reduce bias while maintaining accuracy. Results are normalized to a standard body surface area of 1.73 m² to allow comparison across people of different body sizes.

Where is the eGFR test typically included?

An eGFR test is usually included in a basic or comprehensive metabolic panel, in which serum creatinine is measured, and then eGFR is calculated automatically. This test is also usually part of CKD monitoring panels, often paired with urine albumin‑to‑creatinine ratio (uACR) to assess kidney damage.

eGFR testing is included as part of lab testing through Hers, designed to support a clearer understanding of your health. Results should always be reviewed with a qualified healthcare provider to guide next steps.

Who should get an eGFR test?

There are no universal screening recommendations for low‑risk, asymptomatic adults. eGFR testing is recommended for those at higher risk of CKD, including people with diabetes, high blood pressure, or heart disease, and those with a family history of kidney disease or a history of acute kidney injury.

How Labs by Hers works

  • 1

    Book your test

    Schedule a lab draw in the Hers app at one of more than 2,000 convenient locations.

  • 2

    Get your results

    Review your lab results to understand which areas of your health may need attention.

  • 3

    Spot early signals

    Identify potential health risks or system imbalances before they become more serious.

  • 4

    Get your action plan

    Receive expert guidance tailored to your health profile and test results.

  • 5

    Improve over time

    Track your progress through a mid-year panel and ongoing provider check-ins.

Not available in all 50 states. Eligibility and provider order required. Lab results alone are not intended to diagnose, treat, or cure any condition. A provider will reach out about critical results and plans include access to 24/7 provider messaging.

Images for illustrative purposes only.

Frequently asked questions

Start testing

What causes changes in eGFR?

Decreased eGFR may be due to chronic kidney diseases, diabetes-related kidney damage, blood vessel damage from high blood pressure, some autoimmune diseases, acute kidney injury, dehydration, or certain medications that affect the kidneys (such as NSAIDs or some antibiotics). 

Increased eGFR (that is, abnormally high numbers, usually above 120 mL/min) could be caused by early diabetic hyperfiltration, an early stage of diabetes-related kidney damage.

Do I need to fast for an eGFR test?

No fasting is needed.

Can I check eGFR at home?

Some mail‑in labs measure creatinine and report eGFR, but results require professional interpretation.

How often should I test eGFR?

At least annually for people with diabetes, and likely more often if you’ve been diagnosed with CKD. Check with your provider if you have other risk factors, such as heart disease, high blood pressure, or a family history of kidney issues. 

Does age affect eGFR?

Yes. eGFR declines gradually with age; levels above 60 can be normal in older adults without other signs of kidney damage.

What’s the difference between creatinine and eGFR?

Creatinine is the blood test; eGFR is the equation‑based estimate of filtration, which is more clinically useful for CKD staging.

What does an eGFR below 15 mean?

It generally indicates kidney failure and the need for dialysis or transplant evaluation.

What tests are related to this biomarker?

Serum creatinine

Blood urea nitrogen (BUN)

• Urine albumin‑to‑creatinine ratio (uACR)

• Comprehensive metabolic panel (CMP)

• Kidney ultrasound (if abnormalities are suspected)

The information provided here is for informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always talk to a qualified healthcare provider about your specific health concerns.

Related biomarkers

Start testing

Blood Urea Nitrogen (BUN)

Blood urea nitrogen (BUN) measures the amount of urea, a waste product from protein breakdown, in your blood. Normal levels mean your kidneys are doing a good job of clearing protein waste.

Learn more about Blood Urea Nitrogen (BUN)

BUN/Creatinine Ratio

This marker compares protein waste (BUN) and creatinine to give a reading on hydration and protein metabolism. A normal ratio suggests healthy fluid balance and that your kidneys are handling protein waste well.

Learn more about BUN/Creatinine Ratio

Creatinine

Creatinine is a waste product from muscle activity, like exercise, that the kidneys filter out of the blood. A normal Creatinine level shows that the kidneys are working well and doing a good job of filtering.

Learn more about Creatinine

On your marks.

Get set.

Transform.

Find your baseline with 130+ biomarker tests, then plan for your health breakthrough.

Start testing

Supporting references

Sources

Reviewed by Felix Gussone, MD

Published 12/04/2025