Rx only

Acne Cream

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Tap into smooth, clear skin with customized topical prescription Acne Cream made with powerful, effective ingredients that dermatologists love.

Meet the Acne Rx Cream

  • Tretinoin boosts skin cell turnover to purge acne and improve texture

  • Clindamycin and niacinamide target acne and balance oil production

  • Azelaic acid acts as an anti-inflammatory to reduce inflammation and even hyperpigmentation

How it works

  • Apply this acne treatment once daily (at night!) after cleansing and before or after moisturizing, depending on your skin’s sensitivity

  • Due to the powerfully effective ingredients, you might start with a staggered application schedule—every third or every other night to start before working up to daily applications

  • Start seeing improvement in just weeks, with full results after about 3 months


Press out a precisely dosed amount of cream and spread it over your face at night as directed by your provider, usually starting with every 2-3 nights, working up to nightly over time. Use it after cleansing, then follow with a moisturizer to help prevent dry skin afterward as needed


Active Ingredients: Tretinoin, niacinamide, azelaic acid, and clindamycin.

Base Ingredients: C13-15 Alkane, Caprylyl Methicone, Cyclopentasiloxane, Diethylene Glycol Monoethyl Ether, Dimethicone, Dimethyl isosorbide, Moringa oil/Hydrogenated Moringa oil esters, Passiflora edulis seed oil, PEG-12 Dimethicone/PPG-20 Crosspolymer, Pentaerythrityl Tetraisostearate, Polysilicone-11, Tocopherol, Tocopheryl acetate

Do not use this medication if you are allergic to: tretinoin, clindamycin, niacinamide or azelaic acid.

Common side effects of the Acne Cream (which often go away with time and daily use) include: irritation, itching, redness, dryness, peeling, burning, stinging, and increased sensitivity to the sun.

You should avoid other products known to cause skin irritation such as medicated or abrasive soaps, chemical hair removers or waxes, electrolysis, products with alcohol or astringents, and cosmetics with a strong drying effect. Stop using the Acne Cream if you become pregnant or are breastfeeding.

* Only available if prescribed after an online consultation with a healthcare provider.

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Acne Cream



How Hers works

Answer simple questions

Tell us about your acne so a provider can make the best recommendation

Get a professional recommendation

A licensed medical provider can prescribe treatment, if it’s right for you

Get free shipping

If prescribed, your custom Rx Acne Cream ships free, right to your door sun

See results after just one jar

With proper application you should start seeing the results you want in just a few weeks.

Proven ingredients, real results

  • Help to clear acne, pimples, and blemishes
  • Works to prevent future breakouts before they happen
  • Developed with dermatologists

Prescription skincare made simple

Through Hers, you can get customized Acne Cream prescribed by a licensed medical provider—without leaving home.

The step your skincare routine is missing

Directions: Hers prescription Acne Cream is designed to glide into your nighttime skincare routine to deliver powerful ingredients overnight.


Step 1: Clear Waters Hydrating Cleanser
Step 2: Toner, serum
Step 3: Hydrobounce Instant Moisturizer
Step 4: Prescription Acne Cream
Step 5: Effortless Glow Face Oil

The Purge is real—but necessary

The Purge is a temporary phase you may experience thanks to the tretinoin in your custom Acne Cream. Tretinoin is a retinoid that kickstarts cell turnover to unclog pores, clear acne, and improve skin’s texture.

Week 1-4

The Purge is in full force, and you may experience worsening acne, redness, flaking, and peeling

Week 4-8

As skin begins to adjust, you may start seeing results like acne beginning to heal and texture improving

Week 8-12+

Clear skin is just around the corner with smoother, clearer skin emerging

Get the facts on skin care

Learn more about acne, derm-approved treatments, and medication options specifically designed for women.

9 Ways to Treat Infected Acne
Kristin Hall, FNP
How to Treat Acne Around The Mouth
Katelyn Hagerty, FNP

Frequently asked questions about our acne cream

What is tretinoin?

Tretinoin is a vitamin A derivative commonly used to treat certain skin conditions like acne and aging when used topically . Topical tretinoin increases the rate of skin cell turnover, which can help to clear acne and reduce fine lines associated with aging as well as fade dark spots. Tretinoin is a powerful, prescription-only acne medication from the family of retinoids, which includes a wide variety of treatments, from the oral medication isotretinoin used to treat severe acne to over the counter retinol treatments typically used for milder skin conditions.

What is niacinamide?

Niacinamide is a form of vitamin B3 that is available in a variety of foods, oral supplements and topical creams for acne. In its topical form, niacinamide is often combined with other active ingredients in acne treatments. Niacinamide is available over the counter in facial creams and as an oral health supplement.

What is clindamycin?

Clindamycin is an antibiotic available in oral and topical forms to treat a wide range of bacterial infections. When added to facial treatments, clindamycin can be effective by reducing acne-causing bacteria. Clindamycin is available only with a prescription from a healthcare provider and is often combined with other active ingredients to treat acne, such as tretinoin or benzoyl peroxide.

What causes acne?

Acne occurs when dead skin cells and oil block hair follicles, which allows bacteria to grow and causes inflammation and irritation. There are many forms of acne, including whiteheads, blackheads, pimples and cysts. Most people experience some form of acne in their lifetime, especially teenagers and women at specific times during their menstrual cycle. Acne ranges from occasional mild breakouts to severe, painful acne that occurs regularly. Mild breakouts may be treatable with over the counter products like salicylic acid or prescription treatment containing a retinoid like tretinoin, while severe acne may require oral antibiotic therapy or an oral retinoid (e.g., isotretinoin).

What is the best treatment for acne?

The best treatment for acne depends on your skin type and the root cause of your acne. Many people find that the occasional, mild pimple or breakout can be treated with over the counter drugstore products, such as an acne spot treatment, benzoyl peroxide or salicylic acid. Recurring mild to moderate acne may require a prescription topical treatment, such as clindamycin or tretinoin. Severe acne may require an oral antibiotic or isotretinoin regimen. If you have sensitive skin or a condition like eczema or rosacea, you may need to use caution when choosing acne products. While there is not a single “best” treatment, an online or in-person consultation with a medical provider can help you to figure out what will work best for your particular situation. Click "start consultation" above to connect with a provider.

How do you apply acne cream?

Apply topical acne treatments to the affected area as directed, typically once or twice daily, to clean, dry skin. Apply the medication evenly by rubbing in gently. Before applying, cleanse the skin gently and pat dry. Applying a moisturizer after acne cream may help restore skin barrier as well as negate potential irritation from the treatment itself. If you have sensitive skin, you may need to use acne cream a few days a week at first and gradually work up to daily use. The tretinoin in acne cream has an exfoliating effect, so there is typically no need to exfoliate your skin beyond the application of acne cream. Additionally, retinoids like tretinoin can increase your skin’s sensitivity to the sun, so be sure to wear a sunscreen of SPF 30 or higher every day while using acne cream.

What face wash and moisturizer should I use with acne cream?

Acne cream with tretinoin is an effective acne treatment cream, but it is only one part of a good acne skincare routine. While using acne cream, you will want to avoid any products that clog pores or irritate your skin to get the best results. Look for a non-comedogenic, fragrance-free cleanser and moisturizing lotion to complement your acne cream. If you have particularly oily skin, look for an oil-free cleanser. Be sure to scan any cleanser and moisturizer for other acne-fighting ingredients, such as benzoyl peroxide, tea tree oil or glycolic acid. Combining different acne treatment ingredients could increase risk of irritation, so be sure to talk to your healthcare provider if you are experiencing redness or discomfort. When in doubt, look for a gentle cleanser and moisturizer for sensitive skin. Better yet, get the full Clear Skin System from hers for a perfect three-step skincare routine delivered to your door.

Is acne cream available over the counter?

Our acne cream is available by prescription only because it contains prescription-strength ingredients that you can’t get in even maximum strength OTC acne products. Prescription acne cream can effectively treat more severe forms of acne, like cystic acne. While there is no guarantee that any acne treatment will leave you acne-free, many women who were unable to effectively treat acne before find success with a prescription acne cream.

Learn more about Rx acne creams

Important safety information

Learn more about Rx acne creams

Important safety information

Acne care as it should be

  • 100% customized formulas, 100% online process
  • Only dermatologist-trusted prescription treatments
  • Free shipping, delivered right to your door

Acne care as it should be

  • 100% customized formulas,
    100% online process
  • Only dermatologist-trusted prescription treatments
  • Free shipping, delivered right to your door

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