Rx only

Acne Cream

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Tap into smooth, clear skin with customized topical prescription Acne Cream made with powerful, effective ingredients that dermatologists love.

Meet the Acne Rx Cream

  • Tretinoin boosts skin cell turnover to purge acne and improve texture

  • Clindamycin, zinc pyrithione, and niacinamide target acne and balance oil production

  • Azelaic acid acts as an anti-inflammatory to reduce inflammation and even hyperpigmentation

How it works

  • Apply this acne treatment once daily (at night!) after cleansing and before or after moisturizing, depending on your skin’s sensitivity

  • Due to the powerfully effective ingredients, you might start with a staggered application schedule—every third or every other night to start before working up to daily applications

  • Start seeing improvement in just weeks, with full results after about 3 months


Press out a precisely dosed amount of cream and spread it over your face at night as directed by your provider, usually starting with every 2-3 nights, working up to nightly over time. Use it after cleansing, then follow with a moisturizer to help prevent dry skin afterward as needed


Active Ingredients: Tretinoin, niacinamide, azelaic acid, clindamycin, and zinc pyrithione.

Base Ingredients: C13-15 Alkane, Caprylyl Methicone, Cyclopentasiloxane, Diethylene Glycol Monoethyl Ether, Dimethicone, Dimethyl isosorbide, Moringa oil/Hydrogenated Moringa oil esters, Passiflora edulis seed oil, PEG-12 Dimethicone/PPG-20 Crosspolymer, Pentaerythrityl Tetraisostearate, Polysilicone-11, Tocopherol, Tocopheryl acetate

Do not use this medication if you are allergic to: tretinoin, clindamycin, niacinamide, azelaic acid or zinc pyrithione.

Common side effects of the Acne Cream (which often go away with time and daily use) include: irritation, itching, redness, dryness, peeling, burning, stinging, and increased sensitivity to the sun.

You should avoid other products known to cause skin irritation such as medicated or abrasive soaps, chemical hair removers or waxes, electrolysis, products with alcohol or astringents, and cosmetics with a strong drying effect. Stop using the Acne Cream if you become pregnant or are breastfeeding.

* Only available if prescribed after an online consultation with a healthcare provider.

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Acne Cream



How Hers works

Answer simple questions

Tell us about your acne so a provider can make the best recommendation

Get a professional recommendation

A licensed medical provider can prescribe treatment, if it’s right for you

Get free shipping

If prescribed, your custom Rx Acne Cream ships free, right to your door sun

See results after just one jar

With proper application you should start seeing the results you want in just a few weeks.

Proven ingredients, real results

  • Help to clear acne, pimples, and blemishes
  • Works to prevent future breakouts before they happen
  • Developed with dermatologists

Prescription skincare made simple

Through Hers, you can get customized Acne Cream prescribed by a licensed medical provider—without leaving home.

Ingredients dermatologists trust and your skin will love

Tretinoin (Up to .055%)

This rockstar retinoid (vitamin A derivative) can treat acne, improve the appearance of fine lines, and diminish the look of dark spots in ways OTC skin care products can’t

Clindamycin (Up to 1%)

Acne-forming bacteria’s worst enemy—an antibacterial ingredient that treats current pimples and can protect against future breakouts

Azelaic Acid (Up to 10%)

Hyperpigmentation who? Azelaic acid helps combat dark spots and reduce redness-causing inflammation

Zinc Pyrithione (Up to .25%)

Puts up a fight against bacteria, inflammation, and fungus that can cause blemishes (good riddance!)

Niacinamide (Up to 4%)

Tried and true B3 derivative that can decrease excess oil production, reduce inflammation, and help skin retain moisture

Real women. Really good skin.

Real women.
Really good skin.

4.5 Average Rating

Before/after images shared by customers who have purchased varying products, including prescription based products. These customers’ results have not been independently verified. Individual results will vary. Customers were given free product.

The step your skincare routine is missing

Directions: Hers prescription Acne Cream is designed to glide into your nighttime skincare routine to deliver powerful ingredients overnight.


Step 1: Clear Waters Hydrating Cleanser
Step 2: Toner, serum
Step 3: Hydrobounce Instant Moisturizer
Step 4: Prescription Acne Cream
Step 5: Effortless Glow Face Oil

The Purge is real—but necessary

The Purge is a temporary phase you may experience thanks to the tretinoin in your custom Acne Cream. Tretinoin is a retinoid that kickstarts cell turnover to unclog pores, clear acne, and improve skin’s texture.

Week 1-4

The Purge is in full force, and you may experience worsening acne, redness, flaking, and peeling

Week 4-8

As skin begins to adjust, you may start seeing results like acne beginning to heal and texture improving

Week 8-12+

Clear skin is just around the corner with smoother, clearer skin emerging

Get the facts on skin care

Learn more about acne, derm-approved treatments, and medication options specifically designed for women.

9 Ways to Treat Infected Acne
Kristin Hall, FNP
How to Treat Acne Around The Mouth
Katelyn Hagerty, FNP

Frequently asked questions about our acne cream

What is tretinoin?

Tretinoin is a vitamin A derivative commonly used to treat certain skin conditions like acne and aging when used topically . Topical tretinoin increases the rate of skin cell turnover, which can help to clear acne and reduce fine lines associated with aging as well as fade dark spots. Tretinoin is a powerful, prescription-only acne medication from the family of retinoids, which includes a wide variety of treatments, from the oral medication isotretinoin used to treat severe acne to over the counter retinol treatments typically used for milder skin conditions.

What is niacinamide?

Niacinamide is a form of vitamin B3 that is available in a variety of foods, oral supplements and topical creams for acne. In its topical form, niacinamide is often combined with other active ingredients in acne treatments. Niacinamide is available over the counter in facial creams and as an oral health supplement.

What is clindamycin?

Clindamycin is an antibiotic available in oral and topical forms to treat a wide range of bacterial infections. When added to facial treatments, clindamycin can be effective by reducing acne-causing bacteria. Clindamycin is available only with a prescription from a healthcare provider and is often combined with other active ingredients to treat acne, such as tretinoin or benzoyl peroxide.

What causes acne?

Acne occurs when dead skin cells and oil block hair follicles, which allows bacteria to grow and causes inflammation and irritation. There are many forms of acne, including whiteheads, blackheads, pimples and cysts. Most people experience some form of acne in their lifetime, especially teenagers and women at specific times during their menstrual cycle. Acne ranges from occasional mild breakouts to severe, painful acne that occurs regularly. Mild breakouts may be treatable with over the counter products like salicylic acid or prescription treatment containing a retinoid like tretinoin, while severe acne may require oral antibiotic therapy or an oral retinoid (e.g., isotretinoin).

What is the best treatment for acne?

The best treatment for acne depends on your skin type and the root cause of your acne. Many people find that the occasional, mild pimple or breakout can be treated with over the counter drugstore products, such as an acne spot treatment, benzoyl peroxide or salicylic acid. Recurring mild to moderate acne may require a prescription topical treatment, such as clindamycin or tretinoin. Severe acne may require an oral antibiotic or isotretinoin regimen. If you have sensitive skin or a condition like eczema or rosacea, you may need to use caution when choosing acne products. While there is not a single “best” treatment, an online or in-person consultation with a medical provider can help you to figure out what will work best for your particular situation. Click "start consultation" above to connect with a provider.

How do you apply acne cream?

Apply topical acne treatments to the affected area as directed, typically once or twice daily, to clean, dry skin. Apply the medication evenly by rubbing in gently. Before applying, cleanse the skin gently and pat dry. Applying a moisturizer after acne cream may help restore skin barrier as well as negate potential irritation from the treatment itself. If you have sensitive skin, you may need to use acne cream a few days a week at first and gradually work up to daily use. The tretinoin in acne cream has an exfoliating effect, so there is typically no need to exfoliate your skin beyond the application of acne cream. Additionally, retinoids like tretinoin can increase your skin’s sensitivity to the sun, so be sure to wear a sunscreen of SPF 30 or higher every day while using acne cream.

What face wash and moisturizer should I use with acne cream?

Acne cream with tretinoin is an effective acne treatment cream, but it is only one part of a good acne skincare routine. While using acne cream, you will want to avoid any products that clog pores or irritate your skin to get the best results. Look for a non-comedogenic, fragrance-free cleanser and moisturizing lotion to complement your acne cream. If you have particularly oily skin, look for an oil-free cleanser. Be sure to scan any cleanser and moisturizer for other acne-fighting ingredients, such as benzoyl peroxide, tea tree oil or glycolic acid. Combining different acne treatment ingredients could increase risk of irritation, so be sure to talk to your healthcare provider if you are experiencing redness or discomfort. When in doubt, look for a gentle cleanser and moisturizer for sensitive skin. Better yet, get the full Clear Skin System from hers for a perfect three-step skincare routine delivered to your door.

Is acne cream available over the counter?

Our acne cream is available by prescription only because it contains prescription-strength ingredients that you can’t get in even maximum strength OTC acne products. Prescription acne cream can effectively treat more severe forms of acne, like cystic acne. While there is no guarantee that any acne treatment will leave you acne-free, many women who were unable to effectively treat acne before find success with a prescription acne cream.

Learn more about Rx acne creams

Important safety information

Learn more about Rx acne creams

Important safety information

Important Safety Information

What is the most important information that I should know about the Acne Treatment?
  • Do not use the Acne treatment if you are:
  • Allergic to any of the ingredients that may be found in the acne formulas, including*:
  • Tretinoin
  • Clindamycin
  • Niacinamide
  • Azelaic Acid
  • Zinc Pyrithione
*We offer a variety of formulas to address specific skin concerns in addition to acne, including dark spots and redness. The formulas may contain some or all of the ingredients listed above. If you are allergic to any of these ingredients, please discuss which formula is right for you with your healthcare provider.
  • Younger than 13 years of age
  • If you have severe cystic acne (you should be evaluated in-person by a healthcare provider)
Can I use the Acne Treatment while I am pregnant or breastfeeding?:
We offer 2 acne formulas for pregnant and breastfeeding women that do not contain tretinoin. Tretinoin should not be used during pregnancy and breastfeeding. Topical clindamycin, niacinamide, azelaic acid, and zinc pyrithione are all generally considered safe for use during pregnancy and breastfeeding. Please inform the healthcare provider who is overseeing your pregnancy and/or postpartum period that you are using this product. The Acne treatment is free of the following ingredients:
  • Gluten
  • Parabens
  • Phthalates
  • Sulfate
  • Synthetic fragrance
What if I am currently using a product containing a retinoid (tretinoin, Retin-A®, Tazorac®, or over-the-counter retinol)?
Please stop the treatment that you are currently using and continue using the Acne Treatment in the same fashion. While using the Acne Treatment, please do not use any other treatments on your face that contain a retinoid (including over-the-counter products)
What are the most common side effects of this medication:
You may experience side effects with this medication. These side effects are common and typically go away with time and regular use:
  • Stinging of the skin
  • Irritation
  • Itching
  • Burning
  • Redness
  • Dryness
  • Peeling
  • Increased sensitivity to the sun
You should also avoid other products known to cause skin irritation on the area of treatment, such as medicated or abrasive (rough) soaps, products with alcohol or astringents, chemical hair removers, and cosmetics with a strong drying effect. If you are having any treatments such as a facial, electrolysis, or waxing, please inform the individual providing the service that you are using a product with tretinoin.
What should I tell my healthcare provider before the Acne Treatment is prescribed?
  • If you are pregnant, planning to become pregnant, or breastfeeding
  • If you are currently using any products containing a retinoid (e.g., tretinoin, Retin-A®, Tazorac®, over-the-counter retinol)
  • If you have a hypersensitivity or allergy to tretinoin, other retinoids, or any component of your acne formula
  • If you have a history of perioral dermatitis or rosacea
  • If you have a current or past history of skin cancer
  • If you are currently taking other medications that make you more sensitive to sunlight (e.g., tetracyclines, fluoroquinolones, sulfonamides, thiazides, phenothiazines)
  • If you are currently sunburned on your face
Can I use the Acne treatment more than once a day?
  • No - the treatment is meant to be applied no more than once a day in the evening
Will my skin be more sensitive to the sun while using the Acne Treatment?
  • This treatment may make your skin more susceptible to sunburn and other adverse effects of the sun (this includes the use of tanning beds, artificial sunlamps, etc.). It is important to apply sunscreen on a daily basis with an SPF of at least 15 while using this treatment.
  • What if I get a sunburn while using the Acne treatment?
  • Stop your treatment until your skin has recovered
What type of facial cleanser should I use with the Acne treatment?
  • It is recommended that you wash your face with a 2.5% - 4% benzoyl peroxide wash twice a day. These can be found at most major drugstores or grocery stores. Please do not use abrasive or rough soaps as they may irritate the skin. If your skin is sensitive, you may want to wait 20-30 minutes after washing your face before you apply this treatment.
What will happen once I stop using the Acne Treatment?
  • Once this treatment is stopped, the improvement that you achieved with use may gradually disappear

Go all in for your skin

Acne Cream can be paired with our other derm-loved products for great results.

Clear Waters Cleanser

Wash away pollution, dirt, and makeup buildup—perfect for acne-prone skin

Additional fees may apply

Hydrobounce Instant Moisturizer

Lock in hydration with this lightweight moisturizer formulated with hyaluronic acid

Additional fees may apply

Multi-Screen Mineral Sunscreen SPF 50+

Protects skin from harmful UVA/UVB rays and blue light from devices.

Additional fees may apply

Effortless Glow Face Oil

Antioxidant-rich, 8-oil botanical blend that illuminates your complexion.

Additional fees may apply

Acne care as it should be

  • 100% customized formulas, 100% online process
  • Only dermatologist-trusted prescription treatments
  • Free shipping, delivered right to your door

Acne care as it should be

  • 100% customized formulas,
    100% online process
  • Only dermatologist-trusted prescription treatments
  • Free shipping, delivered right to your door

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