Provided by You Health for patients

In this medication overview

1. Usage

   How to get the most out of your treatment

2. Warnings

   Important safety information

3. Side Effects

   What to look out for when using your treatment

Usage

1. To get started, follow your provider's dosing instructions
   If you are not already taking buspirone, your provider will likely want you to begin by taking a starting dose twice per day for the first 7 days. This may require you to break your pill in half using your hands or an inexpensive pill cutter that can be found at most pharmacies. If your pill splits a bit unevenly, that's okay. Be sure to follow the instructions your provider sent to help your body safely adjust to buspirone.
2. Missed a dose?
   If you miss a dose of buspirone, take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your healthcare provider. Do not double your next dose or take more than what is prescribed.
3. Take as prescribed
   Do not abruptly stop taking buspirone or change your dose without talking with your healthcare provider first, even when you feel better. Studies have shown that a taper can reduce possible side-effects caused by stopping the medication abruptly. Your healthcare provider can provide individualized guidance on tapering your medication. Here are some general guidelines.
   
   If you are taking 40 mg of buspirone (two 10 mg tablets twice a day), take one in the morning (10 mg) and two at night (20 mg) for a week, then one tablet (10 mg) twice a day for a week, then one tablet at night for a week, then you may stop your medication.
   
   If you are taking 30 mg of buspirone (one 15 mg tablet twice a day), take a ½ tablet in the morning (7.5 mg) and one at night (15 mg) for a week, then a ½ tablet twice a day for a week, then a ½ tablet tablet at night for a week, then you may stop your medication.
   
   If you are taking 20 mg of buspirone (one 10 mg tablet twice a day), take one tablet (10 mg) twice a day for a week, then a ½ tablet (5 mg) twice a day for a week, then a ½ tablet once a day at night for a week, then you may stop your medication.
   
   If you are taking 15 mg of buspirone (one 7.5 mg tablet twice a day), a ½ tablet (3.75 mg) twice a day for a week, then a ½ tablet once a day at night for a week, then you may stop your medication.
   
   If you are taking 10 mg of buspirone (one 5 mg tablet twice a day), take one tablet (5 mg) once a day at night for a week, then you may stop your medication.
   
   Your healthcare provider can also provide individualized guidance for tapering your medication
4. Monitor for improvements
   
   You may experience some improvement within the first 1-2 weeks of treatment, but may need up to 6-8 weeks to experience the full benefits.

Warnings

IMPORTANT SAFETY INFORMATION

Do not take Buspirone if you:

• Are allergic to buspirone, or any of the ingredients in buspirone
• Have severe liver or kidney problems
• Have benzodiazepine dependence
• Take any medicines called monoamine oxidase inhibitor (MAOI), or if you have stopped taking and MAOI in the last 14 days including isocarboxazid, phenelzine, rasagiline, selegiline, tranylcypromine
• Take other medication that may cause an increase in serotonin levels such as linezolid, methylene blue, tryptophan
• Take St John’s Wort or 5-Hydroxytryptophan (5-HTP)

Before you take Buspirone, tell your healthcare provider if you:

• Have thoughts of suicide or harming yourself
• Have a history of psychiatric or medical problems, including bipolar disorder
• Have taken any medication in the past for your condition, whether effective or not
• Have suffered adverse or side effects from previous medication therapies
• Are receiving any non-medication treatment, such as talk therapy
• Drink alcohol or use/abuse recreational or prescription drugs
• Are pregnant, plan to become pregnant, or are breastfeeding

Inform your healthcare provider

Until you experience how this medication affects you, do not drive a car, operate potentially dangerous machinery, or perform other dangerous activities.

• You should take buspirone consistently, either always with or always without food.
• During your treatment with buspirone, avoid drinking large amounts of grapefruit juice.
• Avoid drinking alcoholic beverages while taking this medication.

Buspirone may affect the way other medicines work, and other medicines may affect the way buspirone works, causing side effects. Especially tell your healthcare provider if you take any of the following:

• Psychotropic agents, including haloperidol (Haldol®)
• Certain antihypertensives: diltiazem (Cardizem®, Cartia®, Tiazac®) or verapamil (Calan®, Isoptin SR®, Verelan®)
• Erythromycin
• Certain antifungals including itraconazole or ketoconazole
• Nefazodone
• Rifampin
• CYP3A4 inducers: dexamethasone or certain anticonvulsants (phenytoin, phenobarbital, carbamazepine)
• CYP3A4 inhibitors: ritonavir

Other Interactions

• Grapefruit juice - Drinking large amounts of grapefruit juice may cause an increase in the concentration of buspirone in your plasma.

Watch for changes in behavior

The safety of this medication during pregnancy has not been evaluated. If you become pregnant or decide to try to conceive, please alert your provider who will direct you to follow up with your primary care provider or OBGYN for continued management.

Avoid alcohol

Avoid cannabis use

Medication disposal

If no drug take back sites, locations, or programs are available in your area, and there are no specific disposal instructions (such as flushing) in the medication guide or package insert, you can visit FDA- Disposal of Unused Medicines for more information or follow these simple steps to dispose of most medicines in your trash at home:

• Mix medicines (liquid or pills; do not crush tablets or capsules) with an unappealing substance such as dirt, cat litter, or used coffee grounds;
• Place the mixture in a container such as a sealed plastic bag;
• Throw away the container in your trash at home; and
• Delete all personal information on the prescription label of empty medicine bottles or medicine packaging, then trash or recycle the empty bottle or packaging.

Side Effects:

Buspirone can cause serious side effects and should be reported to your provider immediately. Rarely reported side effects include:

• Chest pain
• Restlessness or an inability to remain still
• Involuntary or uncontrolled movements of the body
• Hostility or depression
• Rash, hives, swelling, or trouble breathing
• Serotonin syndrome (symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death)

During treatment with this medication, common side effects of this medication may go away as your body adjusts to the medication. The most common side effects of Buspirone are:

• Dizziness
• Lightheadedness
• Drowsiness
• Diarrhea
• Nausea
• Headache
• Insomnia
• Nervousness
• Excitement
• Mild congestion

Where to find more side effects information